Understanding the biological mechanisms involved in treatment free remission of chronic myeloid leukaemia

了解慢性粒细胞白血病无治疗缓解的生物学机制

• 批准号: nhmrc : 1138079
• 金额: $ 21.82万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-biological-mechanisms-myeloid-leukaemia/1318666
• 关键词: Understanding; biological; mechanisms; involved; treatment

Most patients with chronic myeloid leukaemia achieve excellent responses to therapy but need therapy for life. We have pioneered the concept that some patients can cease their therapy and not relapse (treatment free remission –TFR). By studying the immune system, the leukaemic stem cells and the bone marrow environment, we will determine why TFR is possible for some, but not all patients. This holds the key to improving the rate of TFR, thus moving the CML goal from disease control to cure.

大多数慢性粒细胞白血病患者对治疗有良好的反应，但需要终生治疗，通过研究免疫系统，白血病干细胞，一些患者可以停止治疗而不复发（无治疗缓解 - TFR）。和骨髓环境，我们将确定为什么 TFR 对于某些患者（但不是所有患者）是可能的，这是提高 TFR 率的关键，从而将 CML 目标从疾病控制转向治愈。