Targeting autophagy to improve protein metabolism in ALS

靶向自噬改善 ALS 中的蛋白质代谢

• 批准号: nhmrc : 1104295
• 负责人: Dr Bradley Turner
• 金额: $ 40.19万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-autophagy-improve-metabolism-als/662740
• 关键词: Targeting; autophagy; improve; protein; metabolism

One common feature of MND is the accumulation of protein deposits inside nerve cells which leads to their death. We have identified a potent drug which enhances autophagy, a protective process which breaks down protein deposits inside cells. We have shown that this autophagy enhancer efficiently clears protein deposits linked to MND in the Petri dish. We propose to treat MND mice with this autophagy enhancer and predict that it will slow disease signs, preserve lifespan and protect nerve cells.

MND 的一个共同特征是神经细胞内蛋白质沉积物的积累，从而导致神经细胞死亡。我们已经发现了一种增强自噬的有效药物，自噬是一种分解细胞内蛋白质沉积的保护过程。我们已经证明，这种自噬增强剂可以有效清除培养皿中与 MND 相关的蛋白质沉积物。我们建议用这种自噬增强剂治疗 MND 小鼠，并预测它将减缓疾病症状、延长寿命并保护神经细胞。