Restoring defective protein homeostasis in frontotemporal dementia

恢复额颞叶痴呆中缺陷的蛋白质稳态

• 批准号: nhmrc : 1137024
• 负责人: Dr Bradley Turner
• 金额: $ 48.69万
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/restoring-defective-protein-frontotemporal-dementia/1318546
• 关键词: Restoring; defective; protein; homeostasis; frontotemporal

Frontotemporal dementia (FTD) is associated with pathological accumulation and aggregation of toxic proteins in affected brain regions. This project will employ a novel high throughput drug screening platform technology, FTD patient-derived nerve cells and genetic mouse models to screen drugs to improve clearance of toxic proteins and nerve cell health. This approach should accelerate discovery of agents to potentially treat the underlying cause of FTD in an effort to slow disease progression.

额颞痴呆（FTD）与受影响的大脑区域中有毒蛋白的病理积累和聚集有关。该项目将采用一种新型的高通量药物筛查平台技术，FTD患者衍生的神经细胞和遗传小鼠模型来筛查药物，以提高有毒蛋白质和神经细胞健康的清除。这种方法应加速发现药物以潜在地处理FTD的根本原因，以减缓疾病的进展。