Targeting autophagy to improve protein metabolism in ALS

靶向自噬改善 ALS 中的蛋白质代谢

• 批准号: nhmrc : GNT1104295
• 负责人: A/Pr Bradley Turner
• 金额: $ 58.6万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-autophagy-improve-metabolism-als/1346348
• 关键词: Targeting; autophagy; improve; protein; metabolism

One common feature of MND is the accumulation of protein deposits inside nerve cells which leads to their death. We have identified a potent drug which enhances autophagy, a protective process which breaks down protein deposits inside cells. We have shown that this autophagy enhancer efficiently clears protein deposits linked to MND in the Petri dish. We propose to treat MND mice with this autophagy enhancer and predict that it will slow disease signs, preserve lifespan and protect nerve cells.

MND的一个共同特征是神经细胞内蛋白质沉积物的积累，从而导致其死亡。我们已经确定了一种有效的药物，该药物增强了自噬，这是一种保护性过程，可打破细胞内部的蛋白质沉积物。我们已经表明，这种自噬增强剂有效清除了与培养皿中MND相关的蛋白质沉积物。我们建议用这种自噬增强剂治疗MND小鼠，并预测它将减慢疾病的迹象，保留寿命并保护神经细胞。