Biomolecular assemblies and soft nanostructured materials

生物分子组装体和软纳米结构材料

• 批准号: 327200-2007
• 负责人: Harden, James
• 金额: $ 3.79万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=397630
• 关键词: Biomolecular; assemblies; soft; nanostructured; materials

The proposed research program combines studies in two thematic areas of soft matter: soft glassy nanostructured materials and protein-based biomolecular assemblies. These studies will combine light scattering, diffusing wave spectroscopy, mechanical rheometry, and x-ray photon correlation spectroscopy methods with materials synthesis and computational modeling. In the research program on soft glassy materials, we will study the formation and aging of several model soft nanostructured materials (temperature reversible nanoparticle gels, nanoemulsions under shear, and polymer melts and elastomers near the glass transition) with a focus on understanding the effects of mechanical deformation on the formation and aging processes. In the research program on protein-based biomolecular assemblies, we will develop new elastomeric protein materials (associating protein networks and elastomeric protein polymers), and investigate the roles of their modular domains in determining their structural and viscoelastic properties.

拟议的研究计划结合了软物质两个主题领域的研究：软玻璃纳米结构材料和基于蛋白质的生物分子组装体。这些研究将光散射、扩散波光谱、机械流变测量和 X 射线光子相关光谱方法与材料合成和计算建模结合起来。 在软玻璃材料的研究项目中，我们将研究几种模型软纳米结构材料（温度可逆纳米粒子凝胶、剪切下的纳米乳液以及接近玻璃化转变的聚合物熔体和弹性体）的形成和老化，重点是了解机械变形对形成和时效过程的影响。 在基于蛋白质的生物分子组装体的研究计划中，我们将开发新的弹性蛋白材料（关联蛋白质网络和弹性蛋白聚合物），并研究其模块化结构域在确定其结构和粘弹性特性方面的作用。