The role of cytokines in tumor-induced immunosuppression

细胞因子在肿瘤诱导的免疫抑制中的作用

• 批准号: nhmrc : 1021139
• 负责人: A/Pr Michele Teng
• 金额: $ 50.31万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-cytokines-tumor-induced-immunosuppression/110093
• 关键词: role; cytokines; tumor; induced; immunosuppression

Cancer-induced immune suppression is a major obstacle to the effective treatment of many cancers. We have shown that the cytokine IL-23, plays an important role in cancer initiation, growth and development. My project aims to characterize the cells that produce IL-23 in the cancer microenvironment and define how it suppresses cells of the immune system. A greater understanding of this cytokine’s mechanism of action will enable the rational improvement of treatments for patients with cancer

癌症引起的免疫抑制是许多癌症有效治疗的主要障碍，我们已经证明细胞因子 IL-23 在癌症的发生、生长和发展中发挥着重要作用。 23 在癌症微环境中的作用，并定义它如何抑制免疫系统细胞。更好地了解这种细胞因子的作用机制将有助于合理改进癌症患者的治疗。