Combined T cell checkpoint blockade to eradicate established cancer

联合 T 细胞检查点阻断可根除既定癌症

• 批准号: nhmrc : 1059862
• 负责人: A/Pr Michele Teng
• 金额: $ 13.84万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/combined-t-cell-established-cancer/454790
• 关键词: Combined; cell; checkpoint; blockade; eradicate

We will use combinations of antibodies to rescue exhausted immune effector T cells in cancers or deplete those T cells that suppress tumor immunity. These exciting new approaches have potential curative impact for the treatment of many human cancers. The mouse has been a useful predictive model and in mice, we will aim to study the combinatorial efficacy and mechanism of action of the most promising antibodies and design a new and more specific means to deplete intratumor regulatory T cells.

我们将使用抗体组合来拯救癌症中耗尽的免疫效应 T 细胞或耗尽那些抑制肿瘤免疫的 T 细胞。这些令人兴奋的新方法对治疗许多人类癌症具有潜在的疗效。小鼠是一种有用的预测模型，在小鼠中，我们的目标是研究最有前途的抗体的组合功效和作用机制，并设计一种新的、更具体的方法来消除肿瘤内调节性 T 细胞。