Role of ABCA-G transporters in neuronal cholesterol regulation and Alzheimers disease

ABCA-G转运蛋白在神经元胆固醇调节和阿尔茨海默病中的作用

• 批准号: nhmrc : 510148
• 负责人: A/Pr Woojin Kim
• 金额: $ 37.18万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-abca-g-alzheimers-disease/95766
• 关键词: Role; ABCA; transporters; neuronal; cholesterol

Alzheimer's disease (AD) prevalence is rising and the contributing factors are poorly understood. Recent research shows that cholesterol regulates the production of neurotoxic amyloid-beta peptide (Abeta). We will study a class of proteins, ABC transporters, that we believe regulate neuronal cholesterol and Abeta metabolism. We will use isolated brain cells, human brain tissue and genetically engineered mice in order to define how cholesterol influences AD and identify new treatment options.

阿尔茨海默病 (AD) 的患病率正在上升，但其致病因素却知之甚少。最近的研究表明，胆固醇调节神经毒性淀粉样β肽（Abeta）的产生。我们将研究一类蛋白质，即 ABC 转运蛋白，我们认为它可以调节神经元胆固醇和 Abeta 代谢。我们将使用分离的脑细胞、人脑组织和基因工程小鼠来确定胆固醇如何影响 AD 并确定新的治疗方案。