Role of ABCA8 transporter in oligodendroglial lipid regulation and multiple system atrophy

ABCA8转运蛋白在少突胶质细胞脂质调节和多系统萎缩中的作用

• 批准号: nhmrc : 1022325
• 负责人: A/Pr Woojin Kim
• 金额: $ 43.44万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-abca8-transporter-multiple-atrophy/110181
• 关键词: Role; ABCA8; transporter; oligodendroglial; lipid

Multiple system atrophy (MSA) is a rapid-onset brain disorder impacting on multiple functions of the body resulting in death. The cause of MSA is unknown and there is no cure. In MSA brains, the oligodendroglial cells are impaired and cannot properly make myelin (specialized lipid membrane), which is required for the proper functioning of the nerve cells in the brain. The aim of this project is to find out how changes in lipid in the brain impact on the MSA disease process.

多系统萎缩症（MSA）是一种快速发作的脑部疾病，影响身体的多种功能，导致死亡。 MSA 的病因尚不清楚，也无法治愈。在多发性硬化症患者的大脑中，少突胶质细胞受损，无法正常制造髓鞘质（特殊的脂质膜），而髓鞘质是大脑中神经细胞正常运作所必需的。该项目的目的是找出大脑中脂质的变化如何影响 MSA 疾病的进程。