How blood vessel stiffness regulates their growth and maintenance

血管硬度如何调节其生长和维持

• 批准号: DE240101055
• 负责人: Dr Lilian Schimmel
• 金额: $ 31.08万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240101055
• 关键词: How; blood; vessel; stiffness; regulates

This project aims to reveal an unidentified molecular mechanism of how endothelial cells in the walls of blood vessels detect stiffness of the surrounding environment in order to regulate blood vessel growth and maintenance. The results are expected to advance the emerging field of mechanobiology by combining cutting-edge cell biology and microscopy techniques carried out in novel 3D cell culture and unique quail models. The benefits of these outcomes include generation of knowledge on the impact of tissue stiffness on the signalling mechanisms that drive formation and maintenance of blood vessels. In the long term, this fundamental understanding could give rise to major developments in emerging industries such as organ bioengineering.

该项目旨在揭示一种未知的分子机制，即血管壁中的内皮细胞如何检测周围环境的僵硬，以调节血管的生长和维持。预计该结果将通过结合新型3D细胞培养和独特的鹌鹑模型中的尖端细胞生物学和显微镜技术来推动机械生物学的新兴领域。这些结果的好处包括生成有关组织刚度对驱动血管形成和维持的信号传导机制的影响的知识。从长远来看，这种基本理解可能会引起器官生物工程等新兴行业的重大发展。