Center for Zoonotic and Emerging Infectious Diseases

人畜共患病和新发传染病中心

• 批准号: 9100428
• 负责人: MARK T QUINN
• 金额: $ 108万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9100428
• 关键词: Address; Area; Bioterrorism; Centers of Research Excellence; Communicable Diseases; Core Facility; Crowding; Development; Disease; Domestic Animals; Emerging Communicable Diseases; Environment; Equipment; Exposure to; Faculty; Fostering; Foundations; Future; Goals; Grant; Human; Immune response; Immunotherapeutic agent; Infectious Diseases Research; Mentors; Montana; Pathogenesis; Pilot Projects; Play; Population; Positioning Attribute; Research; Research Infrastructure; Research Personnel; Resources; Role; Solid; Structure; career development; density; disorder prevention; global health; infrastructure development; interest; meetings; novel therapeutics; programs; research facility; synergism; weapons

Zoonotic and emerging infectious diseases represent an increasing and very real threat to global health, and it is essential that we expand our understanding of the pathogenesis and prevention of these diseases because of the increasing density of human populations, the increased exposure to domestic animal populations, and the crowding of wildlife into limited areas with frequent human contact. To address the growing need for infectious disease research, a COBRE Center of Excellence was established at MSU, with the goal of positioning Montana as a national leader in research on zoonotic infectious diseases. Over the past 9 years, the Center has been extremely successful, resulting in infrastructure development (facilities & equipment), recruitment and support of junior investigators (7 COBRE Projects, 6 new hires, and 20 Pilot Projects), and formation of a cohesive Center of investigators. The synergism of these components has resulted in the establishment of a solid foundation for infectious disease research in the region. Importantly, these efforts have fostered faculty career development and have created a pipeline of new researchers with interest and expertise in infectious disease pathogenesis. With this solid infrastructure foundation in place, we are now ideally poised for Center transition to a sustainable research enterprise. Our long term goal is to maintain a sustainable Center of Excellence that is focused on understanding the mechanisms of pathogenesis, host immune response, and immunotherapeutic development for zoonotic and emerging infectious diseases of regional and worldwide importance. The primary goal of COBRE III is to facilitate transition of the Center into a sustainable entity with state-of-the-art research core facilities and a vibrant research environment. Through COBRE III efforts, we also seek to maintain and enhance the critical mass of investigators needed to support future program initiatives. While the foundation and infrastructure for achieving these goals have been established during COBRE l/ll, there is still a critical need for infrastructure optimization and acquisition of additional researchers in the area of infectious diseases to enrich the group and facilitate programmatic efforts. The transition to Center sustainability will be stimulated by an enhanced Pilot Grants Program that will expand the scope and impact of Center research and increase the number of collaborative efforts leading toward larger program-type grants. Likewise, the transition to Center sustainability will involve solidfying scientific Core structure and optimizing utilization of Core research facilities/resources. Finally, Center transition will be enhanced by career development initiatives, such as educational programs and mentoring activities, to meet the needs of all Center-associated investigators. Importantly, this Center will continue to be highly interactive and collaborative and will play an important role in expanding the infectious disease research enterprise in Montana.

人畜共患病和新出现的传染病对全球构成了日益严重的现实威胁 健康，我们有必要扩大对这些疾病发病机制和预防的了解 由于人口密度的增加、接触家庭环境的增加而导致的疾病 动物数量，以及野生动物聚集在人类频繁接触的有限区域。致地址 传染病研究日益增长的需求，在密歇根州立大学建立了 COBRE 卓越中心， 目标是将蒙大拿州定位为人畜共患传染病研究的全国领先者。超过 过去9年，该中心取得了巨大成功，基础设施得到了发展 （设施和设备）、初级研究人员的招聘和支持（7 个 COBRE 项目、6 名新员工以及 20 个试点项目），并组建一个有凝聚力的研究人员中心。这些成分的协同作用 为该地区传染病研究奠定了坚实的基础。 重要的是，这些努力促进了教师的职业发展，并创造了新的渠道 对传染病发病机制感兴趣并具有专业知识的研究人员。有了这个坚实的基础设施 基础已经到位，我们现在已经做好了中心向可持续研究企业转型的理想准备。 我们的长期目标是维持一个可持续的卓越中心，专注于理解 人畜共患病的发病机制、宿主免疫反应和免疫治疗开发 以及具有区域和全球重要性的新发传染病。 COBRE III 的主要目标是 促进该中心转型为一个拥有最先进研究核心设施的可持续实体， 充满活力的研究环境。通过 COBRE III 的努力，我们还寻求维持和增强 需要大量的研究人员来支持未来的计划举措。虽然基础和 实现这些目标的基础设施已经在 COBRE l/ll 期间建立，但仍然存在迫切需求 用于基础设施优化和在传染病领域招募更多研究人员 充实小组并促进计划工作。将刺激向中心可持续发展的过渡 通过增强的试点资助计划，该计划将扩大中心研究的范围和影响 增加协作努力的数量，从而获得更大的计划型赠款。同样， 向中心可持续发展的过渡将涉及巩固科学的核心结构和优化利用 核心研究设施/资源。最后，职业发展将促进中心转型 举措，例如教育计划和指导活动，以满足所有与中心相关的需求 调查人员。重要的是，该中心将继续保持高度互动和协作， 将在扩大蒙大拿州传染病研究事业方面发挥重要作用。