Center for Zoonotic and Emerging Infectious Diseases

人畜共患病和新发传染病中心

• 批准号: 7902317
• 负责人: MARK T QUINN
• 金额: $ 98.89万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2012-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7902317
• 关键词: Center; Zoonotic; Emerging; Infectious; Diseases

Zoonotic and emerging infectious diseases represent an increasing and very real threat to global health, and it is essential that we expand our understanding of the pathogenesis and prevention of these diseases because of the increasing density of human populations, the increased exposure to domestic animal populations, and the crowding of wildlife into limited areas with frequent human contact. To address the need for infectious disease research capabilities, a COBRE Center of Excellence was established at Montana State University (MSU), with the goal of positioning Montana as a national leader in research on the pathogenesis of zoonotic infectious diseases. Over the past four years, the Center has been extremely successful, resulting in development of infrastructure, recruitment and support of junior investigators, and formation of a cohesive Center of investigators. The synergism of these components has resulted in the establishment of a solid foundation for expansion of infectious disease research in the region. With this infrastructure in place, we are now ideally poised to expand and strengthen the Center as a scalable and sustainable research enterprise. Our long term goal is to establish a sustainable Center of Excellence that is focused on understanding pathogenesis, host immune responses, and therapeutic development for zoonotic and emerging infectious diseases of regional and worldwide importance. While the foundation for this goal has been established through accomplishments realized during COBRE I, there is still a critical need for further faculty development, infrastructure enhancement, and recruitment of additional researchers in the area of zoonotic and emerging infectious diseases, and three specific aims are proposed to address these needs. First, we propose a pipeline to foster the development of current junior investigators so that funding and infrastructure resources are available at cntical junctures in their careers. Secondly, we propose to increase the size, scope, and competitiveness of the Center through four new faculty hires. Together, accomplishment of these two aims will lead to establishment of the critical mass of investigators needed to sustain the Center and support future infectious disease research initiatives. Finally, we propose to strengthen the infectious disease research infrastructure in Montana through support and enhancement of established COBRE core facilities. Because of the success of COBRE I, the proven scientific abilities of the Center investigators, the outstanding institutional support, and the emphasis on a timely and increasingly important area of research, we believe that COBRE II support will lead to completion of a scalable and sustainable Center of Excellence in zoonotic and emerging infectious disease research.

人畜共患病和新出现的传染病对全球构成了日益严重的现实威胁 健康，我们有必要扩大对这些疾病发病机制和预防的了解 由于人口密度的增加、接触家庭环境的增加而导致的疾病 动物数量，以及野生动物聚集在人类频繁接触的有限区域。到 为了满足传染病研究能力的需求，COBRE 卓越中心成立 成立于蒙大拿州立大学 (MSU)，目标是将蒙大拿州定位为国家级大学 人畜共患传染病发病机制研究的领导者。在过去的四年里， 中心非常成功，基础设施、招聘和支持都得到了发展 初级调查员的数量，并形成一个有凝聚力的调查员中心。这些的协同作用 成分为传染病的蔓延奠定了坚实的基础 该地区的研究。有了这些基础设施，我们现在就可以进行扩展和 加强该中心作为一个可扩展和可持续研究企业的地位。 我们的长期目标是建立一个可持续的卓越中心，专注于理解 人畜共患病和新发传染病的发病机制、宿主免疫反应和治疗开发 具有区域和世界重要性的疾病。虽然这个目标的基础已经建立 通过 COBRE I 期间取得的成就，仍然迫切需要更多的教师 人畜共患病领域的发展、基础设施增强和招募更多研究人员 和新出现的传染病，并提出了三个具体目标来满足这些需求。首先，我们 提出一个渠道来促进当前初级研究人员的发展，以便资金和基础设施 在他们职业生涯的关键时刻可以获得资源。其次，我们建议增加规模， 通过聘请四名新教员来扩大中心的范围和竞争力。齐心协力，成就 这两个目标将导致建立维持该中心所需的临界数量的调查人员 并支持未来的传染病研究计划。最后，我们建议加强感染力 通过支持和加强已建立的 COBRE 核心，在蒙大拿州建立疾病研究基础设施 设施。由于 COBRE I 的成功，中心研究人员的科学能力得到证实， 杰出的机构支持，以及对及时且日益重要的研究领域的重视， 我们相信 COBRE II 的支持将导致建成一个可扩展且可持续的卓越中心 人畜共患病和新发传染病研究。