Pandemic Preparedness: Biocontainment Facility Upgrade and Integration at UTMB/Galveston National Laboratory

流行病防范：UTMB/加尔维斯顿国家实验室的生物防护设施升级和集成

基本信息

批准号：
10611097
负责人：
Gary Kobinger
金额：
$ 713.18万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-16 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10611097
关键词：
2019-nCoV Address Africa African Air Algorithms American Type Culture Collection Animals Antigens Antiviral Agents Applied Research Arboviruses Area Automation Award Basic Science Biomedical Research Biotechnology Bioterrorism Bunyavirales COVID-19 COVID-19 pandemic Carbon Dioxide Cells Centers for Disease Control and Prevention (U.S.)Cessation of life Clinical Research Clinical Sciences Collaborations Collection Communicable Diseases Communication Communities Complex Computer Security Containment Core Facility Coronavirus Country Culicidae Dangerousness Data Storage and Retrieval Department of Defense Development Diagnosis Diagnostic Differential Diagnosis Disease Disease Outbreaks Disease Vectors Drainage procedure Duct (organ) structure Ebola Ebola Vaccines Ebola virus Educational process of instructing Electronics Emergency Situation Emerging Communicable Diseases Ensure Environment Environmental Health Epidemic Equipment Evaluation Exercise Faculty Family Family Picornaviridae Filovirus Financial Support Fire - disasters Flaviviridae Foundations Freezing Funding Future Goals Government HIV Home Hospitals Human Human Resources Immunity Infection Infectious Agent Infectious Disease Immunology Infectious Diseases Research Influenza A Virus, H1N1 Subtype Influenza A virus Information Technology Infrastructure Institutes Institution International Investigation Joints Journals Laboratories Laboratory Research Lead Leadership Learning Letters Licensure Maintenance Malaria Marburgvirus Measures Medical Medical Research Medical Staff Middle East Respiratory Syndrome Mission Modeling Modernization Modification National Institute of Allergy and Infectious Disease Nature Nurses Paramyxovirus Pathogenesis Pathogenicity Pharmacologic Substance Police Positioning Attribute Prevention Prevention approach Principal Investigator Privatization Procedures Professional Practice Public Health Publications Publishing RNA RNA Viruses Reader Readiness Reagent Recording of previous events Regulation Reporting Research Research Design Research Institute Research Personnel Research Project Grants Role Running Safety Science Scientist Sea Security Services Ships Side Structure Support System System Systems Integration Techniques Testing Texas Therapeutic Therapeutic Monoclonal Antibodies Ticks Time Training Training and Education Translating Translational Research Treatment Efficacy Tropical Disease United States United States Food and Drug Administration United States National Institutes of Health Universities Vaccine Research Vaccines Vector-transmitted infectious disease Veterinarians Vial device Viral Virus Virus Diseases Washington West Nile virus Work World Health Organization Writing ZIKA Zaire Ebola virus Zoonoses animal model development animal resource animal rule antigen diagnostic base bench to bedside biocontainment facility biodefense biopharmaceutical industry biosafety level 4 facility biosecurity chikungunya combat communication device cyber security diagnostic tool drug candidate drug testing end of life exhaust experience firewall good laboratory practice improved infectious disease treatment interdisciplinary approach laboratory experience medical countermeasure meetings mortality multidisciplinary next generation operation pandemic disease pandemic influenza pandemic preparedness pathogen practical application professional atmosphere public health emergency repository research and development research facility respiratory virus response screening statistics therapeutic development therapeutically effective transmission process vaccine development vector-borne ventilation virtual virus development weapons

项目摘要

PROJECT SUMMARY/ABSTRACT Toward maintaining and improving pandemic preparedness, we propose value-added facility upgrades that better integrate the high-containment communities at the University of Texas Medical Branch (UTMB), Galveston. UTMB laboratories integrate operations through joint-facility management, usage, and collaborations that include educating the next generation of research scientists and medical staff. The UTMB community contains the Robert E. Shope Laboratory (Shope)—the first full-sized BSL-4 facility within a university in the United States, a structurally separate high-containment Galveston National Laboratory (GNL), and BSL3 laboratories of Mary Moody Northen Pavilion (MMNP). Each facility supports multiple experienced, published, and governmentally-funded investigators researching pathogens with pandemic potential, as well as facilitating biomedical research of vaccines and therapeutics. Our corpus of researchers includes 31 experts in one or more of six out of the seven RNA viruses of focus by NIAID toward Pandemic Preparedness. The requested financial support will enhance facility capabilities and security within an integrated system of services and operational functions that support the mandate of the GNL within the UTMB high-containment community. We propose to enhance integration of systems to provide a comprehensive protection of all UTMB high-containment facilities against cyberattack, while improving workflow, biosafety, biosecurity, and training capacities through modernization of specific antiquated high-containment areas that are also essential to pandemic responsivity. Of priority is to upgrade equipment and supportive infrastructure utilized in high-containment RNA viral research reaching “end-of-life” (EOL) or “end-of-service” (EOS), prior to experiencing difficulties procuring parts or having stoppage resulting in lost time, funds, and mitigating preparedness. Additionally, we will remedy specific infrastructural shortcomings to improve facility operations. Furthermore, as a leader in teaching the future investigators of high-consequence pathogens, the GNL proposes to upgrade a training area to better reflect the actual BSL4 environment. We will meet these goals through three Aims: Aim 1: Integrate cybersecurity systems under the GNL isolated protection, while modernizing safety and security of virtual and physical structures of UTMB high-containment facilities. Aim 2: Modernize facility and equipment of integrated usage among UTMB’s research community directly in support of BSL3 and BSL4 RNA research of viruses with high pandemic or weaponization potential. Aim 3: Implement pandemic preparedness toward effective future strategic response capacity. Ultimately, modernizations and integrations of systems, operations, and training will better position UTMB to contribute as a global research leader in discovery and development of solutions against high- consequence pathogens. This proposal is framed to provide enhanced security and capacities to further support our roles as collaborator, reference center and repository, institutional model, and trainer toward strategic implementation of a global pandemic preparedness.

项目概要/摘要为了维持和改善大流行病的防备，我们建议进行增值设施升级，更好地整合德克萨斯大学医学分校 (UTMB) 的高封闭社区，加尔维斯顿 UTMB 实验室通过联合设施管理、使用和协作来整合运营。其中包括教育下一代研究科学家和医务人员。包含 Robert E. Shope 实验室（Shop）——美国大学内第一个全尺寸 BSL-4 设施美国，结构独立的高安全性加尔维斯顿国家实验室 (GNL) 和 BSL3 Mary Moody Northen Pavilion (MMNP) 的每个实验室均支持多个经验丰富、已发表文章的实验室。和政府资助的研究人员研究具有大流行潜力的病原体，并促进我们的研究人员包括一项或多项领域的 31 名专家。 NIAID 重点关注的 7 种 RNA 病毒中的 6 种用于流行病防范所需的资金。支持将增强综合服务和运营系统内的设施能力和安全性我们建议在 UTMB 高遏制社区内支持 GNL 的职能。加强系统集成，为所有 UTMB 高密闭设施提供全面保护抵御网络攻击，同时通过以下方式改善工作流程、生物安全和培训能力对特定过时的高遏制区域进行现代化改造，这对于应对大流行病也至关重要。当务之急是升级高遏制 RNA 病毒研究中使用的设备和支持性基础设施在采购零件遇到困难或拥有零件之前达到“寿命终止”(EOL) 或“服务终止”(EOS) 停工导致时间、资金损失和减轻准备工作。此外，我们将采取具体补救措施。此外，作为未来教学的领导者。对于高后果病原体的研究人员，GNL 提议升级培训区，以更好地反映我们将通过三个目标来实现这些目标：目标 1：集成网络安全系统。在GNL隔离保护下，同时实现虚拟和物理结构的安全和保障现代化 UTMB 高密闭设施目标 2：实现 UTMB 综合使用设施和设备的现代化。研究界直接支持高流行性病毒的 BSL3 和 BSL4 RNA 研究目标 3：实施大流行病防备，以实现有效的未来战略应对。最终，系统、运营和培训的现代化和集成将更好地定位。 UTMB 作为全球研究领导者，致力于发现和开发针对高风险的解决方案该提案旨在提供增强的安全性和能力以进一步支持。我们作为合作者、参考中心和存储库、机构模型和战略培训师的角色实施全球大流行防范。