Training Program in Quantitative Ocular Genomics

定量眼部基因组学培训计划

• 批准号: 8800555
• 负责人: Milam A Brantley
• 金额: $ 14.86万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8800555
• 关键词: Genomics; Training Programs

Human genetics has emerged over the past 50 years as a dominant force in biology and medicine. This critical position stems not only from its central importance in explaining the most basic biological processes, but also from its growing repertoire of critical technologies and methods that can elucidate molecular, cellular, organismal, and population biology. However, the application of these technologies and methods to different diseases and phenotypes has varied greatly. Despite the medical, social, and cultural importance of eyesight, genetic studies of ocular phenotypes have lagged behind other disease entities. This is due in part to the lack of cross-disciplinary training opportunities. The primary goal of this Training Program in Quantitative Ocular Genomics is to fill this gap by training a new generation of ocular researchers who have specific expertise in genomic analysis. The proposed Training Program in Quantitative Ocular Genomics requests two pre-doctoral and four post-doctoral training slots. It builds upon the substantial increase in resources, faculty, facilities, and expertise in both ophthalmology (through the Vanderbilt Eye Institute) and human genetics (through the Center for Human Genetics Research) at Vanderbilt. For pre-doctoral training it also builds upon Vanderbilt's existing pre-doctoral Interdisciplinary Graduate Program (IGP) and its excellent and large pool of student applicants. Our goal is to train future investigators to characterize genetic variation and understand its phenotypic implications on ocular phenotypes in humans. Vanderbilt has particular strengths in statistical genetics, computational genomics, genetic epidemiology, bioinformatics, and clinical and basic ophthalmological research. All pre-doctoral trainees will undergo a rigorous didactic program and intensive research training. Post-doctoral trainees will be integrated into our extensive and rich research environment. We have enhanced this training program with regular seminars, journal clubs, an informal works-in-progress seminar, and an annual retreat. To ensure a balanced and complete training experience, each trainee will be co-mentored by a preceptor with extensive experience in genomics and another in ocular function.

过去 50 年来，人类遗传学已成为生物学和医学领域的主导力量。 这一关键地位不仅源于它在解释最基本的生物学方面的核心重要性。 过程，而且还来自其不断增长的关键技术和方法，这些技术和方法可以阐明 分子、细胞、有机体和群体生物学。然而，这些技术的应用 不同疾病和表型的技术和方法差异很大。尽管 由于视力在医学、社会和文化方面的重要性，眼表型的遗传学研究已经滞后 落后于其他疾病实体。部分原因是缺乏跨学科培训机会。 定量眼部基因组学培训计划的主要目标是通过培训来填补这一空白 新一代眼科研究人员在基因组分析方面拥有特定的专业知识。 拟议的定量眼部基因组学培训计划要求两名博士生和四名博士生 博士后培训名额。它建立在资源、师资、设施和 眼科（通过范德比尔特眼科研究所）和人类遗传学（通过 范德比尔特大学人类遗传学研究中心）。对于博士前培训，它还建立在 范德比尔特现有的博士前跨学科研究生项目（IGP）及其优秀而庞大的 学生申请者池。我们的目标是培训未来的研究人员来表征遗传变异 并了解其表型对人类眼表型的影响。范德比尔特有一个特别的 统计遗传学、计算基因组学、遗传流行病学、生物信息学等方面的优势 眼科临床及基础研究。所有博士前培训生都将接受严格的教学 计划和强化研究培训。博士后实习生将融入我们广泛的 和丰富的研究环境。我们通过定期研讨会加强了这一培训计划， 期刊俱乐部、非正式的正在进行的研讨会和年度静修会。为确保平衡 和完整的培训经验，每位学员将由一位具有丰富经验的导师共同指导 拥有基因组学和眼功能方面的经验。