PAHs: New Technologies and Emerging Health Risks

PAH：新技术和新出现的健康风险

• 批准号: 9066646
• 负责人: Robyn L Tanguay
• 金额: $ 293.73万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-27 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9066646
• 关键词: Address; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biomedical Research; Biostatistics Core; Burn injury; Chemicals; Chemistry; Coal; Communities; Devices; Effectiveness; Environment; Environmental Health; Exposure to; Goals; Health; Human; Laboratories; Modeling; Oregon; Pacific Northwest; Petroleum; Quality of life; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Risk; Risk Assessment; Sampling; Scientist; Site; Superfund; Time; Tobacco; Training; Translational Research; Universities; Work; Zebrafish; base; design; developmental toxicity; improved; innovation; instrumentation; new technology; next generation; pharmacokinetic model; programs; remediation; superfund site; training opportunity

The Oregon State University Superfund Research Program (SRP) is multi-investigator, multi-disciplinary and multi-institutional. In parnternship with Pacific Northwest National Laboratories, and other stakeholders and collaborators, we seek to develop new technologies to assess polycyclic aromatic hydrocarbons (PAHs) found at many of the nation's Superfund sites and assess the risk they pose for human health. The SRP consists of three biomedical research projects, two non-biomedical research projects, Administrative, Research Translation, Community Engagement, Training and two research support cores (Biostatistics and Modeling and Chemistry). Over the next five years of the program we will pursue a number of innovative and high impact research goals including: (1) the first ever study of how humans take-up and excrete carcinogenic PAHs at environmental levels of exposure; (2) produce Physiologically Based Pharmacokinetic (PBPK) models for risk assessment of PAH mixtures; (3) determine developmental toxicities of PAH mixtures and PAHs formed in the environment using a zebrafish model; (4) employ passive sampling devices to assess bioavailable PAHs at Superfund sites and the effectiveness of remediation strategies and; (5) employ new analytical approaches to assessing chemical changes in PAHs in soilds and sediments at Superfund sites over time. The cores will: (1) direct the activities of the SRP (Administrative); (2) pursue effective mechanisms for disseminating our findings to stakeholders (Research Translation), (3) work with communities impacted by PAH exposure to address concerns and pursue solutions for reduced risk (Community Engagement); (4) provide intensive multi-disciplinary training opportunities for the next generation of Environmental Health Scientists (Training) and; (5 and 6) provide Biostatistical and Modeling support for the design, conduct and interpretation of the research being conducted as well as using state-of-the- art Chemistry instrumentation and approaches to assess the identity and quantity of hundreds of PAHs found in environmental and biological matricies. Accomplishing these goals will provide significant scientific advancement and improve the quality of life for impacted communities.

俄勒冈州立大学超级基金研究计划 (SRP) 是一个多研究者、多学科和 多机构。与太平洋西北国家实验室和其他利益相关者合作 合作者，我们寻求开发新技术来评估多环芳烃 (PAH) 在美国许多超级基金地点发现并评估它们对人类健康构成的风险。建议零售价 包括三个生物医学研究项目、两个非生物医学研究项目、行政、 研究翻译、社区参与、培训和两个研究支持核心（生物统计学和 建模和化学）。在该计划的未来五年中，我们将追求许多创新 高影响力的研究目标包括：(1) 首次研究人类如何吸收和排泄 环境暴露水平下的致癌多环芳烃； (2) 产生基于生理学的药代动力学 (PBPK) 多环芳烃混合物风险评估模型； (3)确定PAH混合物的发育毒性 使用斑马鱼模型在环境中形成多环芳烃； (4)采用无源采样装置 评估超级基金地点的生物可利用多环芳烃以及修复策略的有效性； (5) 雇用 超级基金采用新的分析方法评估土壤和沉积物中多环芳烃的化学变化 随着时间的推移网站。核心将： (1) 指导 SRP 的活动（行政）； (二)追求实效 向利益相关者传播我们的研究结果的机制（研究翻译），(3) 与 受多环芳烃接触影响的社区应解决问题并寻求降低风险的解决方案 （社区参与）； (4)为下一步提供强化的多学科培训机会 一代环境健康科学家（培训）； (5 和 6) 提供生物统计和建模 支持正在进行的研究的设计、实施和解释以及使用最新的 评估数百种多环芳烃的特性和数量的化学仪器和方法 存在于环境和生物基质中。实现这些目标将提供重要的科学依据 进步并改善受影响社区的生活质量。