Training Program in Translational Cardiovascular Research and Entrepreneurship

转化心血管研究和创业培训计划

• 批准号: 9035429
• 负责人: Jose S Jalife
• 金额: $ 19.58万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9035429
• 关键词: Cardiovascular system; Entrepreneurship; Research; Training Programs

 DESCRIPTION (provided by applicant): This proposal seeks to develop a new training program in Translational Cardiovascular Research and Entrepreneurship (CVRE) at the University of Michigan. Cardiovascular disease is the leading cause of death worldwide. Therefore, the mission of this program is to train the next generation of PhD scientists seeking careers in cardiovascular research in the ethical development and application of research results from the level of the molecule, through the cellular, intact tissue and animal models, to the bedside, with the ultimate goal of improving therapy for patients. Since this is a pre-doctoral training experience taking place during the last two years of the PhD program after preliminary examination, the emphasis is on an advanced didactic program and independent research. The proposed training program is intentionally designed to address the gap in training of young basic scientists and pre-doctoral students in key areas of translational cardiovascular research such as preclinical research design, drug discovery, device/therapy development, optimization and testing, entrepreneurship, and regulatory compliance. The interdisciplinary and internationally recognized faculty of this program provides an outstanding training environment that includes state of the art facilities and techniques spanning genetic, molecular, cellular, systems, engineering and clinical investigation of both vascular and cardiac diseases. By capitalizing on the existing strengths of our faculty in basic and preclinical cardiovascular research and unique academic resources at the University of Michigan, we will train students not only in state of the art biomedical research, but also in applying systems biology for preclinical testing, navigating regulatory compliance, and entrepreneurship. Therefore, this program offers students a unique comprehensive and immersive experience in translational research training. The added benefit is that it will also prepare students for the diversity of scientific careers available to and typially pursued by young scientists including academic research, start-up companies, biotechnology and large pharmaceutical and device companies. The translational CVRE program will attract students from laboratories across the Frankel Cardiovascular Center faculty membership, the medical school wide Program in Biomedical Sciences, and the School of Engineering. By placing students at the interface between basic cardiovascular research, biomedical engineering, and cardiovascular medicine, we hope to better prepare the next generation of PhD scientists to be the "leaders and best" at taking basic research discoveries and being capable of directing their path to the clinic. (End of Abstract)

 描述（由申请人提供）：该提案旨在在密歇根大学开发一个新的转化心血管研究和创业（CVRE）培训项目心血管疾病是全球死亡的主要原因。培养下一代从事心血管研究的博士科学家，从分子水平到细胞、完整组织和动物模型，再到临床研究结果的伦理发展和应用，最终目标是改善由于这是博士前的治疗。 经过初步审查后的博士课程最后两年的培训经验，重点是高级教学计划和独立研究。拟议的培训计划旨在解决年轻基础科学家和博士前培训方面的差距。该项目的跨学科和国际认可的师资队伍为转化心血管研究关键领域的学生提供了一个出色的培训环境，其中包括临床前研究设计、药物发现、设备/疗法开发、优化和测试、创业和监管合规性。艺术设施和技术涵盖遗传、分子、通过利用我们在基础和临床前心血管研究方面的现有优势以及密歇根大学独特的学术资源，我们将不仅在血管和心脏病的细胞、系统、工程和临床研究方面对学生进行培训。艺术生物医学研究，而且还应用系统生物学进行临床前测试、监管合规性和创业精神，因此，该项目为学生提供了独特的全面和身临其境的转化研究培训体验。的多样性转化性 CVRE 项目将吸引来自弗兰克尔心血管中心教职人员实验室的学生，该项目是年轻科学家通常从事的科学职业，包括学术研究、初创公司、生物技术和大型制药和设备公司。生物医学科学和工程学院通过将学生置于基础心血管研究、生物医学工程和心血管医学之间，我们希望更好地培养下一代博士科学家，使其成为基础研究的“领导者和最佳人选”。发现和存在能够引导他们前往诊所的路径（摘要结束）