Chromatin and Epigenetics

染色质和表观遗传学

基本信息

批准号：
9106870
负责人：
DAVID L. WOODLAND
金额：
$ 0.4万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-01 至 2016-11-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9106870
关键词：
Animal Model Attention Canada Chromatin Chromatin Fiber Chromatin Modeling Chromatin Structure Chromosome Structures Collaborations DNA Discipline Educational workshop Epigenetic Process Eukaryotic Cell Feedback Fostering Gene Expression Regulation Genetic Transcription Genomic approach Health Human Inherited International Knowledge Learning Literature Malignant Neoplasms Methodology Mission National Human Genome Research Institute Nucleosomes Outcome Process RNA Regulation Research Research Personnel Role Scientist Signal Transduction Stem cells The Cancer Genome Atlas Time Transcriptional Regulation Work Yang abstracting base clinical practice enzyme activity epigenetic drug epigenomics histone modification human disease inter-institutional meetings next generation novel posters public health relevance response stem cell biology stem cell fate symposium

项目摘要

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Chromatin and Epigenetics, organized by Luciano Di Croce and Yang Shi. The meeting will be held in Whistler, BC, Canada from March 20-24, 2016. The DNA of eukaryotic cells is organized into chromatin fibers, where the nucleosome is the basic repeating unit. Chromatin is thus at the core of fundamental processes such as gene regulation, stem cell fate determination and cancer. By and large, these topics have traditionally been covered by separated meetings. However, recent literature indicates that the boundaries among these various disciplines are becoming less clear. This meeting will bring together scientists studying chromatin structure, epigenetics, stem cell biology and cancer. The talks will cover a broad range of topics, including chromosome organization, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms and transcription regulation. Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches. Junior scientists will be able to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. There will also be ample time for exchanging ideas and discussing novel hypothesis at the end of each session, as well as time for informal interactions and networking. This meeting is relevant to the NCI mission because of its focus on chromatin and next generation epigenetic drugs. Indeed, The Cancer Genome Atlas, which is jointly administered by NCI and NHGRI, includes an epigenomics component.

描述（由申请人提供）：请求支持由 Luciano Di Croce 和 Yang Shi 组织的题为“染色质和表观遗传学”的 Keystone 研讨会，该会议将于 2016 年 3 月 20 日至 24 日在加拿大不列颠哥伦比亚省惠斯勒举行。真核细胞被组织成染色质纤维，其中核小体是基本重复单位，因此染色质是诸如此类的基本过程的核心。总的来说，这些主题传统上是由不同的会议讨论的，但最近的文献表明，这些不同学科之间的界限变得越来越模糊，这次会议将把研究染色质的科学家聚集在一起。演讲将涵盖广泛的主题，包括染色体组织、长程相互作用、染色质组装、干细胞调控/分化、基于RNA的机制和转录调控。广泛反映从各种模型生物和实验方法将能够通过从提交的摘要中选择的大量简短演讲以及海报展示来展示他们的工作。这次会议与 NCI 使命相关，因为它的重点是染色质和下一代表观遗传药物，事实上，癌症基因组图谱由 NCI 和 NHGRI 联合管理。，包括一个表观基因组学成分。