2022 Membrane Transport Proteins GRC/GRS

2022 膜转运蛋白 GRC/GRS

基本信息

批准号：
9991402
负责人：
AURELIO GALLI
金额：
$ 2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9991402
关键词：
Academia Academy Adderall Address Advocacy Animal Model Anniversary Area Attention deficit hyperactivity disorder Australia Basic Science Biochemical Biogenesis Biological Biophysics Brain Canada Carrier Proteins Cells Cessation of life Christianson syndrome Climate Clinical Collaborations Communities Cystic Fibrosis Data Defect Development Diabetes Mellitus Discipline Disease Diuretics Ensure Environment Europe Fluoxetine Fostering Functional disorder Future Genes Genetic Genetic Diseases Goals Government Hour Human Genome Industry International Invertebrates Ion Channel Ion Pumps Ions Knowledge Lead Leadership Life Link Malignant Neoplasms Medical Medicine Membrane Potentials Membrane Transport Proteins Mental Depression Mentors Metabolic Migraine Mind Minority Molecular Nerve Degeneration Neurologic Neurons Neurotransmitters Nuclear Pore Nutrient Omeprazole Organism Participant Patients Perception Pharmaceutical Preparations Pharmacology Pharmacotherapy Physiological Physiology Policies Postdoctoral Fellow Process Protein translocation Proteins Proton Pump Publishing Rare Diseases Regulation Reporting Research Research Personnel Ritalin SK-Furosemide Science Science, Technology, Engineering and Mathematics Scientist Secondary Schools Secure Selective Serotonin Reuptake Inhibitor Sodium Chloride System Techniques Therapeutic Time Transcranial magnetic stimulation Translating Transmembrane Transport Ulcer Underrepresented Minority Woman Work autism spectrum disorder base career clinically relevant design disease phenotype diversity and inclusion dopamine transporter drug discovery equity diversity and inclusion gender equity genetic variant graduate student improved inhibitor/antagonist innovation insight lectures member neurotransmitter release next generation notch protein novel outreach peer peptide hormone posters prevent programs rare genetic disorder recruit serotonin transporter single-molecule FRET skills success supportive environment symporter symposium therapeutic target trafficking

项目摘要

PROJECT SUMMARY The 2020 Gordon Research Conference on Membrane Transporter Proteins titled “Biomedical Transporters: Physiology, Dysfunction and Targets of Pharmacotherapy” will bring an urgently needed translational focus to research on clinically relevant and highly druggable membrane transporters. Although they account for 10% of the human genome and thought contribute to a gamut of highly prevalent (autism, depression, diabetes) as well as orphan and rare diseases (Christianson syndrome, mucoviscidosis), membrane transporters remain largely unexplored in their potential as therapeutic targets, and in their association to specific diseases. The impetus in organizing this conference is to link genetic, molecular and mechanistic insights on clinically important membrane transporters, including carriers, ion channels and pumps, to physiological function and disease-related malfunction. The intent is to offer and discuss opportunities for the development of pharmacotherapies targeting transporter dysfunctions in disease states. N ine highly interdisciplinary scientific sessions are bringing together topics, approaches and novel ideas that are not conventionally related. These range from genetics of transporter and ion channels in disease states, to unconventional animal models to study transporter, or particular approaches such as single-molecule fluorescence resonance energy transfer and transcranial magnetic stimulation. This prevents the perception of a particular approach or topic dominating the conference and amplifies opportunities for discussion of new ideas. New topics have been introduced (e.g. peptides, hormones, and neurotransmitter release: the importance of transporters in the gut and brain; invertebrates as animal models to study transporter functions, etc.) that have never been covered in this conference. Ample discussion time after each talk, daily posters, and afternoon free time allow for informal discussion, networking and forming new collaborations. Other special features of the 2020 conference include the Gordon Research Seminar for young investigators, and the Power Hour for the promotion of women scientists. Notably, we secured Dr. Imogen Coe as the Discussion Leader of the Power Hour. Dr. Coe is internationally recognized as a Canadian thought leader in the area of equity, diversity and inclusion (EDI) in science, technology, engineering and math (STEM). She has advised academia, government and industry on the best practices and approaches to improve EDI in STEM, particularly in the Canadian post-secondary education (PSE) sector. She has written and spoken about these issues extensively for platforms such as the Globe and Mail, iPolitics and the CBC. In 2016, she was recognized as one of Canada's Top 100 Women for her advocacy work promoting equity in STEM. We feel that this conference will offer plenty of scientific opportunities fostering an environment centered on EDI.

项目概要 2020 年戈登膜转运蛋白研究会议，题为“生物医学转运蛋白：生理学、功能障碍和药物治疗的目标”将为以下领域带来迫切需要的转化焦点：临床相关且高度可成药的膜转运蛋白的研究，尽管它们占 10%。人类基因组和思想也导致了一系列高度流行的疾病（自闭症、抑郁症、糖尿病）作为孤儿和罕见疾病（克里斯蒂安森综合征、粘液粘稠病），膜转运蛋白在很大程度上仍然存在它们作为治疗靶点的潜力以及它们与特定疾病的关联尚未被探索。组织这次会议是将临床上重要的膜的遗传、分子和机制见解联系起来转运蛋白，包括载体、离子通道和泵，影响生理功能和疾病相关目的是提供和讨论针对靶向药物疗法的开发机会。疾病状态下转运蛋白功能障碍。高度跨学科的科学会议汇集了与传统上不相关的主题、方法和新颖想法包括转运蛋白的遗传学。和疾病状态下的离子通道，非常规动物模型来研究转运蛋白，或特定单分子荧光共振能量转移和经颅磁等方法这可以防止某种特定方法或主题在会议中占据主导地位的感觉。增加了讨论新想法的机会（例如肽、激素、和神经递质释放：肠道和大脑中转运蛋白作为动物模型的重要性；研究转运蛋白功能等），这些内容在本次会议中从未涉及过。充足的讨论时间。每次演讲结束后，每日海报和下午的空闲时间可以进行非正式讨论、建立联系并形成新的 2020 年会议的其他特色包括针对年轻人的戈登研究研讨会。值得注意的是，我们聘请了伊莫金·科 (Imogen Coe) 博士。作为 Power Hour 的讨论领袖，科博士是国际公认的加拿大思想领袖。科学、技术、工程和数学 (STEM) 领域的公平、多样性和包容性 (EDI)。为学术界、政府和行业提供有关改进 STEM 中 EDI 的最佳实践和方法的建议，特别是在加拿大高等教育 (PSE) 领域，她撰写并谈论过这些内容。 2016 年，她在《环球邮报》、《iPolitics》和《CBC》等平台上广泛发表问题。作为加拿大 100 名杰出女性之一，她致力于促进 STEM 的公平性，我们认为这一点。会议将提供大量科学机会，营造以 EDI 为中心的环境。