Behavioral and Functional Neuroscience Laboratory

行为和功能神经科学实验室

基本信息

批准号：
8989930
负责人：
Mehrdad Shamloo
金额：
$ 22.28万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-03-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8989930
关键词：
Address Animal Model Behavior Behavior monitoring Behavioral Behavioral Paradigm Biological Assay Brain Infarction Central Nervous System Diseases Clinical Trials Communities Complex Core Facility Data Data Collection Data Set Disease model Faculty Genes Guidelines Home environment Hour Human Implant Intervention Laboratories Learning Memory Microscopy Modeling Monitor Movement Neurosciences Neurosciences Research Phenotype Preclinical Testing Predictive Value Procedures Protocols documentation Publications Recommendation Reporting Reproducibility Resource Sharing Resources Rodent Rodent Model Sampling Services Standardization System Technology Testing Transgenic Organisms United States National Institutes of Health behavior test design drug discovery drug testing improved innovation interdisciplinary collaboration novel optogenetics preclinical efficacy sex social vector web site

项目摘要

Project Summary (BFNL) As one of the three Stanford Neuroscience Cores, the Stanford Behavioral and Functional Neuroscience Laboratory (BFNL). This core facility provides a centralized resource for standard and automated sensorimotor, learning and memory, and social behavioral paradigms as well as expertise in rodent models of CNS disorders in conjunction to pharmacological and experimental drug testing. In addition, automated behavior testing paradigms established by this core have helped our community to further address the standardization and reproducibility of behavioral tests using state-of-the-art apparatuses such as Intellicage and PhenoLab automated home environment monitoring systems. These systems provide complete home- cage sensorimotor behavioral monitoring capabilities and can test simple and complex learning and memory tasks in a fully automated fashion with minimal human intervention. Using this expertise and technology BFNL has provided state-of-the-art phenotyping services for novel transgenic lines and provided validated CNS Disease Models for testing novel compounds and neuropharmacological exploration during the past several years. BFNL has freely shared experimental protocols and data. The detailed list of behavioral paradigms, standard operating procedures, protocols, and a sample data set for most behavioral paradigm has been shared publicly at http://sbfnl.stanford.edu/testingtable. Over the past four years, BFNL has supported 55 labs and faculty with almost 40,000 hours of services. This effort has led to more than 20 publications overall. Going forward BFNL will continue providing these services and allocate additional resources to address more actively some of the rising concerns in the field about the predictive value and inherent limitations of animal models in drug discovery and also innovate and expand upon its automated testing capabilities. All of these advances will be shared with the neuroscience community via our newly improved resource sharing websites.

项目概要（BFNL）作为斯坦福大学三个神经科学核心之一，斯坦福大学行为和功能神经科学实验室（BFNL）。该核心设施为标准和自动感觉运动、学习和记忆、社会行为范式以及啮齿动物方面的专业知识中枢神经系统疾病模型与药理学和实验药物测试相结合。此外，该核心建立的自动化行为测试范式帮助我们的社区进一步解决使用 Intellicage 等最先进的仪器进行行为测试的标准化和可重复性和 PhenoLab 自动化家庭环境监测系统。这些系统提供完整的家庭笼子感觉运动行为监测能力，可以测试简单和复杂的学习和记忆以完全自动化的方式执行任务，只需最少的人为干预。利用 BFNL 的专业知识和技术为新型转基因品系提供最先进的表型分析服务，并提供经过验证的 CNS 过去几年用于测试新化合物和神经药理学探索的疾病模型年。 BFNL 免费共享实验方案和数据。行为范式的详细列表，标准操作程序、协议和大多数行为范式的样本数据集已经在 http://sbfnl.stanford.edu/testingtable 上公开共享。在过去的四年里，BFNL 为 55 个实验室和教员提供了近 40,000 小时的服务支持。这项努力总共发表了 20 多篇出版物。展望未来，BFNL 将继续提供这些服务并分配额外资源，以更积极地解决该领域日益出现的一些问题关于动物模型在药物发现中的预测价值和固有局限性以及创新和扩展其自动化测试能力。所有这些进步都将与神经科学共享通过我们新改进的资源共享网站建立社区。