Bioengineering and Bioimaging Core

生物工程和生物成像核心

基本信息

批准号：
8882463
负责人：
ROBERT A LATOUR
金额：
$ 34.1万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-01 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8882463
关键词：
Advisory Committees Antibodies Area Biocompatible Materials Biomechanics Biomedical Engineering Biomedical Research Bioreactors Cardiac Cellular biology Centers of Research Excellence Circular Dichroism Core Facility Custom Development Diabetes Mellitus Digital Radiography Drug Delivery Systems Drug Design Faculty Fluorescence Funding Goals Grant High Pressure Liquid Chromatography Human Resources Individual Laboratories Link Maintenance Methods Molecular Biology Monitor Names Natural regeneration Nerve Regeneration Phase Polymers Principal Investigator Regenerative Medicine Research Research Personnel Research Support Resistance Resources Roentgen Rays Scanning Probe Microscopes Services South Carolina Stem cells Structure Surface Surface Plasmon Resonance System Systems Development Testing Tissue Engineering Tissues Training Training Support Ultrasonography Universities Vascular Graft Water Work absorption bioimaging bioluminescence imaging design evaluation/testing experience in vivo innovation instrument meetings microCT nanotherapeutic programs quantum sensor soft tissue systems research

项目摘要

Program Director/Principal Investigator (Last, First, Middle): Vyavahare, Naren Project Summary: The Bioengineering and Bioimaging Core The Bioengineering and Bioimaging Core (B5) is composed of four thrust areas, each of which are of critical importance for the support of tissue engineering, regenerative medicine, and drug delivery system research: Biomaterials Characterization, Bioactive Matrix Synthesis and Bioreactor Design, Biomechanics, and Bioimaging. The B5 will work with the targeted COBRE PIs and outside investigators to assist them with planning and conducting their research and in the analysis of their research results in each of these four thrust areas. The Core provides state-of-the-art facilities not normally available in the laboratories of individual investigators. These facilities include a Waters HPLC system; a PerkinElmer Analysis 200 flame atomic absorption spectrophotometer; a JASCO J-810 circular dichroism spectropolarimeter; a SOPRA GES-5 variable angle spectroscopic ellipsometer; a Biacore X surface plasmon resonance spectrometer; a Kruss contact angle goniometer; an Asylum MFP-3D-BIO atomic force microscope; a custom designed multi-functional bioreactor systems; a broad range of biomechanical testing systems for both hard and soft tissues with multiaxial and environmental chamber capabilities; and a suite of in vivo bioimaging systems including digital radiography, ultrasound, IVIS Lumina XR system (fluorescence, bioluminescence imaging and X-ray combined), and Quantum FX microCT (to be purchased). The B5 will staff each of these facilities with experienced supervisors and support personnel, who will be responsible for the maintenance of the Core instruments and who will provide dedicated user training and support. As the only core in the COBRE system (out of > 200) focused on bioengineering and bioimaging, this core represents a vital component of the COBRE Center, which will provide invaluable service and support for the target-PIs as well as outside investigators working in tissue engineering, regenerative medicine, and drug delivery system design. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

项目总监/首席研究员（最后、第一、中间）：Vyavahare、Naren 项目摘要：生物工程和生物成像核心生物工程与生物成像核心（B5）由四个推力区组成，每个推力区都是对于支持组织工程、再生医学和药物输送系统至关重要研究：生物材料表征、生物活性基质合成和生物反应器设计，生物力学和生物成像。 B5 将与目标 COBRE PI 和外部调查人员合作协助他们规划和开展研究并分析他们的研究结果这四个推力区域中的每一个。核心区提供了通常在其他地区无法提供的最先进的设施个别研究人员的实验室。这些设施包括 Waters HPLC 系统；珀金埃尔默分析200火焰原子吸收分光光度计； JASCO J-810 圆二色性分光旋光计； SOPRA GES-5 可变角度光谱椭偏仪； Biacore X 表面等离子共振光谱仪； Kruss接触角测角仪； Asylum MFP-3D-BIO 原子力显微镜；定制设计的多功能生物反应器系统；广泛的生物力学具有多轴和环境室功能的硬组织和软组织测试系统；和一套体内生物成像系统，包括数字放射线摄影、超声波、IVIS Lumina XR 系统（荧光、生物发光成像和 X 射线相结合）和 Quantum FX microCT（待定）购买）。 B5 将为每个设施配备经验丰富的主管和支持人员，谁将负责核心仪器的维护，谁将提供专门的用户培训和支持。作为 COBRE 系统（超过 200 个）中唯一专注于生物工程和生物成像，该核心代表了 COBRE 中心的重要组成部分，它将提供宝贵的为目标 PI 以及组织工程领域的外部研究人员提供服务和支持，再生医学和药物输送系统设计。 OMB 编号 0925-0001/0002（修订版 08/12 已批准至 8/31/2015）页面延续格式页面