Trace Elements (TE)

微量元素 (TE)

• 批准号: 8804003
• 负责人: Brian P Jackson
• 金额: $ 1.83万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-04 至 2019-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8804003
• 关键词: Ablation; Arsenic; Biological; Blood; Brain; Cancer Center Support Grant; Carcinogens; Doctor of Philosophy; Elements; Funding; Future; Image; Immunology; In Situ; Individual; Inductively Coupled Plasma Mass Spectrometry; Inorganic Chemistry; Juice; Lasers; Link; Malignant Neoplasms; Maps; Mercury; Methodology; Methods; Microtomy; Molecular; Nature; Norris Cotton Cancer Center; Platinum; Protocols documentation; Radiobiology; Rattus; Research; Research Personnel; Resolution; Resource Sharing; Resources; Rice; Sampling; Scientist; Selenium; Services; Solutions; Structure of nail of toe; Technology; Therapeutic; Therapeutic Effect; Tissues; Toddler; Trace Elements; Trace metal; abstracting; analytical method; anticancer research; bioimaging; cancer epidemiology; cancer imaging; cancer immunotherapy; innovation; nanoparticle; operation; programs; solid solution; two-dimensional

Project Summary/Abstract: Trace Elements (TE) Shared Resource The Trace Element (TE) Shared Resource is a specialized facility dedicated to determining trace element concentration, and form of trace elements, in a wide variety of biological and environmental media. The chemistry of inorganic elements inextricably is linked with the study of cancer. Whether determining the fate and effects of known carcinogens (such as arsenic), the potential antagonistic effects of elements (such as selenium), or the therapeutic effects of platinum or Fe nanoparticles, there is a clear need for routine advanced trace element analytical methods to support cancer research. The critical nature of these services for the Norris Cotton Cancer Center (NCCC) research program has led to designation of TE as an NCCC-supported Shared Resource and to a request for future CCSG funding. In the TE core, Inductively Coupled Plasma Mass Spectrometry (ICP-MS) methodologies have been developed to provide analysis of trace metals in solids, solution, blood, and toenails. TE services include arsenic speciation in solutions, mercury speciation in solution, and ICP-MS tuning and operation for routine analysis. There have been notable examples of cancer research using TE resources. For example, the TE core developed innovative methods for determining Arsenic species in rice, juice, and toddler formulae. Also TE-developed spatial analyses show the distribution of a trace element within tissue sections, which is determined 'in situ' at pre-determined resolution, creating a 2-dimensional elemental image map from biological thin sections using laser ablation-ICP-MS. Using this technology, the TE core developed methods for detecting Fe, Cu, and Zn in rat brain sections. Analytical expertise is provided by the TE Core Director and a staff consisting of a PhD level scientist and an advanced Research Technician. The TE core has collaborated with NCCC researchers in 5 of the NCCC Programs (Cancer Epidemiology, Cancer Mechanisms, Molecular Therapeutics, Cancer Imaging & Radiobiology, and Immunology & Cancer Immunotherapy) to determine the concentration or form of trace elements in biological samples.

项目摘要/摘要：微量元素 (TE) 共享资源 微量元素 (TE) 共享资源是专门用于确定微量元素的专用设施 各种生物和环境介质中微量元素的浓度和形式。这 无机元素的化学与癌症研究有着千丝万缕的联系。是否决定命运 和已知致癌物（如砷）的影响，元素（如 硒），或铂或铁纳米粒子的治疗效果，显然需要常规先进的 支持癌症研究的微量元素分析方法。这些服务对于 Norris Cotton 癌症中心 (NCCC) 研究计划已将 TE 指定为 NCCC 支持的 共享资源并请求未来 CCSG 资金。在 TE 核心中，电感耦合等离子体质量 光谱测定 (ICP-MS) 方法已被开发用于分析固体中的痕量金属， 溶液、血液和脚趾甲。 TE 服务包括溶液中的砷形态分析、溶液中的汞形态分析 解决方案，以及用于常规分析的 ICP-MS 调谐和操作。有一些著名的癌症例子 使用 TE 资源进行研究。例如，TE 核心开发了创新方法来确定 大米、果汁和幼儿配方奶粉中的砷。 TE 开发的空间分析还显示了分布 组织切片内微量元素的分析，以预定的分辨率“原位”测定，从而创建 使用激光烧蚀-ICP-MS 从生物薄片中获得二维元素图像图。使用这个 技术方面，TE 核心开发了检测大鼠脑切片中铁、铜和锌的方法。分析型 TE 核心总监和由博士级科学家和高级科学家组成的工作人员提供专业知识 研究技术员。 TE 核心与 NCCC 研究人员在 5 个 NCCC 项目中进行了合作 （癌症流行病学、癌症机制、分子治疗学、癌症成像和放射生物学，以及 免疫学和癌症免疫治疗）测定生物中微量元素的浓度或形式 样品。