Animal Shared Resources

动物共享资源

• 批准号: 9067992
• 负责人: Louis M. Weiner
• 金额: $ 19.06万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9067992
• 关键词: Animal Cancer Model; Animal Model; Animal Technicians; Animals; Arts; Autopsy; Basic Science; Cancer Center Support Grant; Carcinogens; Clinic; Comprehensive Cancer Center; Development; Diagnostic radiologic examination; Diet; Doctor of Philosophy; Drug toxicity; Endocrine; Estrogen receptor positive; Genes; Image; Image Analysis; Imaging Device; Laboratory Research; Laboratory Study; Letters; Life Cycle Stages; Link; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Medicine; Modeling; Monitor; Mus; Peer Review; Performance; Pharmaceutical Preparations; Rattus; Research; Resistance; Resolution; Resource Sharing; Resources; Rodent; Rodent Model; Services; Training; Translating; Translations; Tumor Tissue; Ultrasonography; United States National Institutes of Health; Universities; Xenograft procedure; Zebrafish; animal facility; animal imaging; anticancer research; cancer recurrence; comparative; design; imaging modality; in vivo; knockout gene; malignant breast neoplasm; medical schools; member; overexpression; pre-clinical; pre-clinical research; programs; research study; response; screening; spectroscopic imaging; tool; tumor growth; tumor initiation

Animal Models Shared Resource Animal models are powerful cancer research tools and a vital link in translating laboratory studies Into the clinic. The function of the Animal Models Shared Resource (AMSR) is to facilitate efficient economical, and state-of-art use of animals for the performance of cancer-related studies. This is accomplished through a centralized resource, where AALAS-certified, highly trained veterinary technicians provide preclinical research services to LCCC members. A significant emphasis is placed on assisting users with the design and performance of animal studies using a wide-range of models, including zebrafish and a recently developed model to study endocrine resistance and breast cancer recurrence in an estrogen receptor positive rat model. Major services provided include all aspects of rodent studies, such as establishing genetically modified mouse colonies, administrating carcinogens, monitoring tumor growth, collecting tissues and tumors at necropsy, and administering drugs, diets or other compounds. Studies using zebrafish include generating gene knockout or gene overexpressing models, screening for toxicity/drugs, and xenotransplantation experiments. Imaging services are also provided to monitor tumor initiation, progression, and response to therapy. The imaging services provided by AMSR include high resolution in vivo small animal imaging and image analysis using a recently upgraded Bruker 7-Tesla magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) console, a small animal ultrasound (Vevo660) workstation, an X-ray imaging unit (Faxitron) and a visible-near infrared spectroscopic imaging workstation (Maestro II). The AMSR is located within Georgetown University Medical School's Division of Comparative Medicine (DCM). The DCM is a centralized, AAALAC-accredited, USDA-registered animal facility and has an approved letter of assurance on file at the NIH. In 2012, these services were used in support of peer reviewed projects of 18 LCCC members from all four Research Programs. The AMSR is codirected by Leena Hilakavi-Clarke, PhD, and Christopher Albanese, PhD, who oversee the animal and imaging components, respectively

动物模型共享资源动物模型是强大的癌症研究工具，也是将实验室研究转化为诊所的重要联系。动物模型共享资源（AMSR）的功能是促进有效的经济性，并最先进的动物用于与癌症相关研究的进行。这是通过集中资源来完成的，在该资源中，AALAS认证的，训练有素的兽医技术人员为LCCC成员提供临床前研究服务。重要的是使用广泛模型，包括斑马鱼和最近开发的模型，以研究雌激素受体阳性大鼠阳性大鼠模型中的内分泌耐药性和乳腺癌复发，以帮助用户进行动物研究的设计和性能。提供的主要服务包括啮齿动物研究的所有方面，例如建立转基因的小鼠菌落，管理致癌物，监测肿瘤生长，在尸检时收集组织和肿瘤以及施用药物，饮食或其他化合物。使用斑马鱼的研究包括产生基因敲除或过表达基因过表达模型，筛查毒性/药物以及异种移植实验。还提供了成像服务以监测肿瘤的启动，进展和对治疗的反应。 AMSR提供的成像服务包括使用最近升级的Bruker 7-Tesla磁共振成像（MRI）和磁共振光谱（MRS）控制台（MRS）控制台（VEVO660）工作部（VEVO660）工作部（VEVO660）工作部（X-Ray Imbared Impron）（fudaxiber Spectriatiation），使用X-Ray Imbared Spectratiation（fudaxible Spectriatiation） （Maestro II）。 AMSR位于乔治敦大学医学院比较医学部（DCM）内。 DCM是一个集中的，AAALAC认可的，USDA登记的动物设施，并在NIH附有批准的保证书。 2012年，这些服务被用于支持所有四个研究计划的18个LCCC成员的同行审查项目。 AMSR由Leena Hilakavi-Clarke，PhD和Christopher Albanese，Phd，分别监督动物和成像组成部分