Translational Research Training in Pediatric Nephrology

小儿肾脏病学转化研究培训

• 批准号: 9098115
• 负责人: ISIDRO B. SALUSKY
• 金额: $ 6.64万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9098115
• 关键词: Childhood; Nephrology; Research Training; Translational Research

 DESCRIPTION (provided by applicant): The proposed Translational Research Training in Pediatric Nephrology T32 program at the David Geffen School of Medicine at UCLA is designed to prepare outstanding postdoctoral scholars (MDs and/or PhDs) for academic research careers in Pediatric Nephrology and aligned disciplines, at a time of declining numbers of physician-scientists nationwide and of expanding need for improved understanding and management of chronic disease care. During the initial 5-year period, with 4 postdoctoral trainees per year, each for a 2- or, if indicated, 3-year appointment, this new training program will fill a critical need or research focused on a diverse range of developmental issues in chronic kidney disease (CKD) and will advance the goals of interdisciplinary collaboration across the T1-T4 spectrum of translational medicine through rigorous cross- training in the different concepts and methods of basic, clinical, and population- and laboratory-based approaches to CKD, including assessment of health care system impact through health services research and policy analysis. Over the last several decades, major advances have occurred in the diagnosis, treatment, and management of kidney diseases in childhood, altogether resulting in the increased life span of such patients. This success has, however, brought new health status challenges, such as cardiovascular disease (the leading cause of death), muscle-skeletal problems, growth retardation, infections, and allograft loss, among others, all of which are optimally addressed from a developmental perspective. In response to these challenges, the interdisciplinary curriculum and mentored, hands-on research training of this new program encompass the biomedical and clinical sciences, including comparative effectiveness and patient-centered outcomes research, interweaving the scientific expertise and mentoring experience of 35 high-quality multidisciplinary faculty who are committed to collaborative, team-based science. The new training program will leverage the resources of the UCLA Specialty Training and Advanced Research Program, Training Program in Translational Science (former K30), and existing K12, T32, and R25 programs for the core curriculum and protected time, all collectively geared to achieve the following specific aims: (1) expand the multidisciplinary knowledge base of life and health sciences as it relates to different aspects of pediatric kidney diseases; (2) provide didactic and experimental research training in the intellectual and philosophical foundation of clinical-translational research; (3) develop trainees' scientific writing skills for publications ad grants; (4) provide an academic environment that enables development of the research skills and experience needed for successful, independent scientific careers in academic medicine as members and leaders of interdisciplinary teams in cross-cutting research domains germane to Pediatric Nephrology; and (5) model research-empowering teaching and mentoring skills for trainees' development, including their eventual replication of research training programs in life-span CKD and co-morbidities as their careers evolve into stable, scientific independence.

 描述（由申请人提供）：加州大学洛杉矶分校大卫格芬医学院拟议的小儿肾病转化研究培训 T32 项目旨在为小儿肾病和相关学科的学术研究职业培养杰出的博士后学者（医学博士和/或博士） ，在全国医师科学家数量下降以及对改善慢性病护理的理解和管理的需求不断扩大之际，在最初的 5 年期间，有 4 名医生和科学家。每年招收博士后学员 对于 2 年或 3 年（如果有指示）的任命，这一新的培训计划将满足关键需求或专注于慢性肾脏病（CKD）各种发展问题的研究，并将推进跨学科合作的目标T1-T4 转化医学谱，通过对 CKD 的基础、临床、人群和实验室方法的不同概念和方法进行严格的交叉培训，包括通过卫生服务研究和政策分析评估卫生保健系统的影响。过去几十年来，取得了重大进展儿童时期肾脏疾病的诊断、治疗和管理，总体上提高了此类患者的寿命，然而，这一成功也带来了新的健康状况挑战，例如心血管疾病（主要死亡原因）、肌肉骨骼问题、生长迟缓、感染和同种异体移植物损失等，所有这些问题都从发育的角度得到了最佳解决。为了应对这些挑战，这个新项目的跨学科课程和指导性的实践研究培训涵盖了这些问题。生物医学和临床新的培训计划将利用加州大学洛杉矶分校专业培训的资源，包括比较有效性和以患者为中心的结果研究，将 35 名高素质多学科教师的科学专业知识和指导经验结合在一起。高级研究计划、转化科学培训计划（前 K30）以及现有的 K12、T32 和 R25 核心课程和受保护时间计划，所有这些计划共同旨在实现以下具体目标：（1）扩大涉及儿科肾脏疾病不同方面的生命和健康科学的多学科知识库；(2) 提供临床转化研究的知识和哲学基础方面的教学和实验研究培训；(3) 培养学员的科学写作能力；出版物和资助的技能；（4）提供一个学术环境，以培养作为与儿科肾病学相关的跨领域研究领域的跨学科团队的成员和领导者在学术医学领域取得成功、独立的科学职业所需的研究技能和经验；和（5）为学员的发展建立模型研究授权教学和指导技能，包括随着他们的职业发展为稳定、科学的独立性，他们最终复制终生慢性肾病和合并症的研究培训项目。