THE ROLE OF PARATHYROID HORMONE IN RENAL OSTEODYSTROPHY

甲状旁腺激素在肾性骨营养不良中的作用

• 批准号: 7951531
• 负责人: ISIDRO B. SALUSKY
• 金额: $ 43.1万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951531
• 关键词: Chronic; Chronic Kidney Failure; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Dialysis procedure; Funding; Grant; Hemodialysis; Institution; Kidney; Measures; Osteogenesis; Parathyroid Hormones; Renal Osteodystrophy; Research; Research Personnel; Resistance; Resources; Role; Source; United States National Institutes of Health; human PTH protein; skeletal; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: 1. To determine whether PTH concentrations measured by 2nd PTH-IMA provide a more accurate assessment of bone formation and turnover than PTH levels obtained with 1st PTH-IMA in and young adults undergoing chronic hemodialysis. 2. To determine whether PTH concentrations measured by 2nd PTH-IMA provide a more accurate assessment of bone formation and turnover than PTH levels obtained by 1st PTH-IMA in and young adults with chronic kidney disease (CKD) prior to dialysis. 3. To assess the magnitude and progression of renal and skeletal resistance to PTH and to determine whether the abundance of amino-terminally truncated PTH(1-84) fragments contribute to the state of resistance in young adults with CKD prior to dialysis, and of skeletal resistance alone in young adults undergoing chronic hemodialysis.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 具体目标： 1. 确定在接受慢性血液透析的年轻人中，通过第二次 PTH-IMA 测量的 PTH 浓度是否比通过第一次 PTH-IMA 获得的 PTH 水平提供更准确的骨形成和更新评估。 2. 确定在透析前患有慢性肾病 (CKD) 的年轻人中，通过第二次 PTH-IMA 测量的 PTH 浓度是否比通过第一次 PTH-IMA 获得的 PTH 水平提供更准确的骨形成和更新评估。 3. 评估肾脏和骨骼对 PTH 抵抗的程度和进展，并确定氨基末端截短的 PTH(1-84) 片段的丰度是否会导致患有 CKD 的年轻人在透析前的抵抗状态，以及接受慢性血液透析的年轻人仅骨骼抵抗力。