Multi-omics study of ancestry enriched associations in Hispanics/Latinos

西班牙裔/拉丁裔血统丰富关联的多组学研究

基本信息

批准号：
10889299
负责人：
Nora Franceschini
金额：
$ 35万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-21 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10889299
关键词：
APOL1 gene Address Admixture African African ancestry Amino Acids Biological Process Biological Products Cardiometabolic Disease Cardiovascular Diseases Chromosomes Chronic Disease Chronic Kidney Failure Clinical Clinical Data Complement Complex Data Diabetes Mellitus Diagnosis Disease Disease susceptibility Environmental Exposure European Frequencies Gene Frequency Genes Genetic Genetic Risk Genome Genomic Segment Genomics Genotype Goals Health Healthcare Hispanic Community Health Study/Study of Latinos Hispanic Populations Human Individual Inflammatory Inherited Kidney Kidney Diseases Knowledge Latino Population Lipids Maps Measures Mendelian randomization Metabolic Metabolic Diseases Metabolism Minority Groups Mission Molecular Multiomic Data National Human Genome Research Institute Native American Ancestry Native Americans Obesity Participant Pathway interactions Physiological Population Populations at Risk Process Proteins Proteomics Public Health Research Signal Transduction Single Nucleotide Polymorphism Source Susceptibility Gene Testing Trans-Omics for Precision Medicine Variant Whole Blood admixture mapping cardiometabolism clinical biomarkers clinical care clinical phenotype clinical translation clinically relevant cohort disorder risk ethnic minority fatty liver disease genetic association genetic variant genome wide association study genome-wide genomic data improved insight metabolomics mortality multi-ethnic multiple omics novel strategies personalized medicine population based programs protein biomarkers racial minority rare variant social culture trait transcriptome sequencing transcriptomics

项目摘要

ABSTRACT This proposal builds into our ongoing research in genetics and disease risk in admixed Hispanic populations. Hispanics/Latinos are the larger racial/ethnic minority in the U.S. They have a high burden of cardiometabolic and inflammatory related diseases. Genetically, Hispanics are an heterogenous population comprised of multiple ancestral groups (primarily Native American, West African, European) from recent admixture. Few studies have leveraged genetic ancestry to address differences in disease susceptibility. This study will leverage the comprehensive data from the large population-based Hispanic Community Health Study/Study of Latinos for discovery of ancestry-enriched susceptibility loci. We propose to integrate genomics and multi- omics data to map genomic segments and variants inherited from the ancestral population with the higher disease variant frequency (Aim 1), use new approaches for fine-mapping genomic regions (Aim 2), and validate our findings for clinical relevance in Hispanics/Latinos from the All of Us study (Aim 3). We expect to gain insights into the identified ancestry-related genomic regions and variants and their relationship to disease states. This proposal uniquely complements large ongoing genome wide association approaches. Our results may provide insights into differences in disease risk in admixed populations. Ultimately this research could inform personalized medicine and improve public health.

抽象的该提案融入了我们正在进行的西班牙裔混合人群的遗传学和疾病风险研究。西班牙裔/拉丁裔是美国人数最多的种族/少数族裔。他们的心脏代谢负担很高和炎症相关疾病。从基因上看，西班牙裔是一个异质群体，包括来自最近混合的多个祖先群体（主要是美洲原住民、西非、欧洲）。很少研究利用遗传血统来解决疾病易感性的差异。这项研究将利用基于大量人口的西班牙裔社区健康研究/研究的综合数据拉丁裔发现富含祖先的易感位点。我们建议整合基因组学和多学科组学数据用于绘制从祖先群体继承的基因组片段和变异，具有较高的疾病变异频率（目标 1），使用新方法精细绘制基因组区域（目标 2），以及验证我们的研究结果与“我们所有人”研究中西班牙裔/拉丁裔的临床相关性（目标 3）。我们期望深入了解已确定的祖先相关基因组区域和变异及其与疾病的关系州。该提议独特地补充了正在进行的大规模基因组范围关联方法。我们的成果可以提供有关混合人群疾病风险差异的见解。最终这项研究可以为个性化医疗提供信息并改善公共卫生。