Core G: Patient-Oriented Research Core

核心 G：以患者为中心的研究核心

基本信息

批准号：
8142233
负责人：
RONALD GARY TOMPKINS
金额：
$ 46.84万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-30 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8142233
关键词：
16 year old Accident and Emergency department Acute Adult Age Anemia Authorization documentation Biological Biometry Blood Blood Transfusion Blood gas Blood specimen Blunt Trauma Body Surface Area Burn Trauma Burn injury Caring Categories Cervical Childhood Cicatrix Clinical Clinical Investigator Comorbidity Consensus Craniocerebral Trauma Critical Care Data Databases Enrollment Ethnic Origin Failure Family member Fatty acid glycerol esters Functional disorder Gender General Hospitals Genomics Goals Graph Harvest Hemorrhage Hospitals Hour Human Genome Hypotension Immune Incidence Individual Inflammatory Inflammatory Response Information Dissemination Informed Consent Injury Length Literature Measures Mechanical ventilation Metabolic Multiple Organ Failure Muscle Normalcy Organ Outcome Palpable Patients Perfusion Phase Phenotype Physicians Physiological Population Process Proteome Proteomics Publishing Recruitment Activity Research Ethics Committees Resources Risk Sampling Secondary to Severities Skin Tissue Spinal cord injury Taxes Thoracic spinal cord structure Time Tissues Trauma Update Work aged base cohort high risk injured mortality patient oriented research prevent programs response trauma centers

项目摘要

The Patient-Oriented Research Core (PORC) continues to function as originally envisioned to provide the large-scale collaborative project with clinical, physiologic, pathophysiologic, and outcomes data, and samples to support the analyses and interpretation of the numerous phenotypic, proteomic, and genomic alterations and interactions in patients with severe trauma-induced innate immune and particularly inflammatory responses. The Core identifies, recruits, enters, and obtains samples (blood and tissue) from severely injured patients at risk for organ dysfunction/failure, infectious complications, and mortality. The clinical investigators from the PORC also work closely with the Information Dissemination and Data Coordination, Clinical Biostatistics, and Data Interpretation Cores to help make biological and clinical sense of the data.

以患者为导向的研究核心 (PORC) 继续按照最初设想发挥作用，以提供具有临床、生理、病理生理和结果数据和样本的大型合作项目支持对众多表型、蛋白质组和基因组改变的分析和解释患有严重创伤引起的先天免疫，特别是炎症反应的患者之间的相互作用。核心识别、招募、输入并获取重伤患者的样本（血液和组织）器官功能障碍/衰竭、感染并发症和死亡的风险。临床研究人员来自 PORC 还与信息传播和数据协调、临床生物统计学和数据解释核心有助于理解数据的生物学和临床意义。