STUDY OF GLUTAMINE AND GLUTAMATE METABOLISM IN HEALTHY SUBJECTS

健康受试者中谷氨酰胺和谷氨酸代谢的研究

• 批准号: 7731322
• 负责人: RONALD GARY TOMPKINS
• 金额: $ 1.15万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731322
• 关键词: Amino Acids; Computer Retrieval of Information on Scientific Projects Database; Critical Illness; Diet; Enteral Feeding; Funding; Glutamate Metabolism Pathway; Glutamates; Glutamine; Grant; Institution; Metabolic; Muscle Proteins; Patients; Rate; Research; Research Personnel; Resources; Source; Supplementation; United States National Institutes of Health; protein metabolism

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study proposes to quantify the rates of glutamate/glutamine metabolic utilization, conversion, and oxidative disposal in the whole body and splanchnic region of healthy subjects on a diet that follows the amino acid composition of routine and glutamine-enriched enteral feeding formulas. Understanding the metabolic rate of glutamate and glutamine will further serve to examine the effects of glutamine supplementation on support of muscle protein metabolism in healthy subjects. These subjects will serve as controls to evaluate the efficacy of glutamine supplementation in critically ill, severely catabolic patients.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该研究旨在量化健康受试者全身和内脏区域的谷氨酸/谷氨酰胺代谢利用率、转化率和氧化处理率，这些受试者的饮食遵循常规和富含谷氨酰胺的肠内喂养配方的氨基酸组成。 了解谷氨酸和谷氨酰胺的代谢率将进一步有助于检查补充谷氨酰胺对健康受试者肌肉蛋白质代谢的支持作用。 这些受试者将作为对照，评估谷氨酰胺补充剂对危重、严重分解代谢患者的功效。