Core G: Patient-Oriented Research Core

核心 G：以患者为中心的研究核心

• 批准号: 7195417
• 负责人: RONALD GARY TOMPKINS
• 金额: $ 154.94万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7195417
• 关键词: biomedical facility; cooperative study; human subject; medical outreach /case finding; patient oriented research

The Patient-Oriented Research Core (PORC) continues to function as originally envisioned to provide the large-scale collaborative project with clinical, physiologic, pathophysiologic, and outcomes data, and samples to support the analyses and interpretation of the numerous phenotypic, proteomic, and genomic alterations and interactions in patients with severe trauma-induced innate immune and particularly inflammatory responses. The Core identifies, recruits, enters, and obtains samples (blood and tissue) from severely injured patients at risk for organ dysfunction/failure, infectious complications, and mortality. The clinical investigators from the PORC also work closely with the Information Dissemination and Data Coordination, Clinical Biostatistics, and Data Interpretation Cores to help make biological and clinical sense of the data.

以患者为导向的研究核心 (PORC) 继续按照最初设想发挥作用，以提供 具有临床、生理、病理生理和结果数据和样本的大型合作项目 支持对众多表型、蛋白质组和基因组改变的分析和解释 患有严重创伤引起的先天免疫，特别是炎症反应的患者之间的相互作用。 核心识别、招募、输入并获取重伤患者的样本（血液和组织） 器官功能障碍/衰竭、感染并发症和死亡的风险。临床研究人员来自 PORC 还与信息传播和数据协调、临床生物统计学和 数据解释核心有助于理解数据的生物学和临床意义。