CLIONIDINE AND THE SKELETAL MYOPATHY OF HEART FAILURE

可乐定与心力衰竭的骨骼肌病

• 批准号: 8167118
• 负责人: HOLLY R MIDDLEKAUFF
• 金额: $ 0.59万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167118
• 关键词: Chronic; Clonidine; Computer Retrieval of Information on Scientific Projects Database; Exercise Tolerance; Funding; Grant; Heart failure; Institution; Mechanoreceptors; Muscle; Myopathy; Patients; Research; Research Personnel; Resources; Source; Sympatholytics; United States National Institutes of Health; improved; skeletal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim 1. To determine if chronic therapy with another sympatholytic therapy, clonidine, reverses the skeletal myopathy of HF, and increases exercise tolerance. 1.1 Is the chronic decrease in MSNA in HF patients treated with clonidine associated with a reversal of the skeletal myopathy? 1.2 What is the effect of the improved skeletal myopathy on the augmented muscle mechanoreceptor sensitivity in HF?

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 具体目标 1. 确定另一种抗交感神经疗法可乐定的长期治疗是否可以逆转心力衰竭的骨骼肌病并提高运动耐量。 1.1 使用可乐定治疗的心力衰竭患者中 MSNA 的慢性下降是否与骨骼肌病的逆转有关？ 1.2 改善的骨骼肌病对心衰患者肌肉机械感受器敏感性的增强有什么影响？