CARDIAC RESYNCHRONIZATION THERAPY AND THE SKELETAL MYOPATHY OF HEART FAILURE

心脏再同步治疗和心力衰竭的骨骼肌病

• 批准号: 8167111
• 负责人: HOLLY R MIDDLEKAUFF
• 金额: $ 0.07万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167111
• 关键词: Cardiac; Cardiopulmonary; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Heart failure; Institution; Mechanoreceptors; Muscle; Myopathy; Patients; Pressoreceptors; Research; Research Personnel; Resources; Rest; Source; United States National Institutes of Health; receptor; skeletal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1.1 Does CRT reduce resting MSNA chronically in advanced HF? 1.2 Is the skeletal myopathy reversed in HF patients in whom MSNA is decreased following CRT? 1.3 Does an increase in arterial baroreceptor and cardiopulmonary receptor gain underlie this decrease in MSNA following CRT? 1.4 Does reversal of the augmented muscle mechanoreceptor sensitivity in HF contribute to the decrease in MSNA following CRT?

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 1.1 CRT 是否会长期降低晚期心力衰竭患者的静息 MSNA？ 1.2 CRT 后 MSNA 降低的心力衰竭患者的骨骼肌病是否会逆转？ 1.3 动脉压力感受器和心肺感受器增益的增加是否是 CRT 后 MSNA 降低的基础？ 1.4 HF 中增强的肌肉机械感受器敏感性的逆转是否会导致 CRT 后 MSNA 的降低？