Software for meta-analysis with correlated outcomes
用于具有相关结果的荟萃分析的软件
基本信息
- 批准号:8001628
- 负责人:
- 金额:$ 15.04万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-05-01 至 2010-10-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptedAlcoholsAlgorithmsBackCenters for Disease Control and Prevention (U.S.)ComplexComputer softwareDataData SetEcologyEducationGenerationsGerontologyGoalsGrantInstitutionInterventionKnowledgeMedicineMeta-AnalysisOutcomePaperPoliciesProceduresReportingResearchResearch PersonnelSeriesSocial SciencesSolutionsSubstance abuse problemSystemTechniquesTextTimeUnited States National Institutes of HealthUniversity HospitalsWorkdesignevidence basefallsinterestprogramspublic health relevancesoftware development
项目摘要
DESCRIPTION (provided by applicant): Meta-analysis is the statistical procedure employed to synthesize data from a series of studies. As such, it falls at the core of evidence-based policy in such fields as alcohol and substance abuse, medicine, social science, ecology, education, gerontology, among many others. The current generation of meta-analysis software is designed for the situation where each study contributes one (and only one) effect size to the analysis. However, many meta-analyses do incorporate studies that report more than one effect size. In particular, studies sometimes report effects for more than one outcome, for more than one time-point, and/or for more than one intervention. In these cases the standard formulas and software cannot be used, and there are no good options for performing the analysis. The only software that can be used in these cases requires a high level of statistical expertise, and additionally requires the user to provide information, such as the correlation matrix among outcomes, that the user is not likely to have. Therefore, as a practical matter, there are no good options for performing a meta-analysis involving more than one effect size. Under a series of earlier grants we developed a program for meta-analysis that is currently in use at some 10,000 institutions around the world, including thousands of hospitals, universities, and agencies such as the FDA, CDC, NIH, WHO, among many others. Our plan is to expand this to work with studies that report more than one effect size, and that will not require the user to supply a correlation matrix.
PUBLIC HEALTH RELEVANCE: The current generation of software for meta-analysis can only be used when each study provides a single effect size. The goal of this project is to develop software for meta-analysis that can be used when some (or all) studies report an effect for multiple outcomes, time-points, or treatments. This software will not require the user to provide a correlation matrix among effects.
描述(由申请人提供):荟萃分析是用于综合一系列研究数据的统计程序。因此,它是酒精和药物滥用、医学、社会科学、生态学、教育、老年学等领域循证政策的核心。当前一代荟萃分析软件是针对每项研究为分析贡献一种(且仅有一种)效应量的情况而设计的。然而,许多荟萃分析确实纳入了报告多种效应大小的研究。特别是,研究有时会报告不止一种结局、不止一个时间点和/或不止一种干预措施的效果。在这些情况下,无法使用标准公式和软件,并且没有好的选择来执行分析。唯一可以在这些情况下使用的软件需要高水平的统计专业知识,并且还需要用户提供用户不可能拥有的信息,例如结果之间的相关矩阵。因此,实际上,没有好的选择来执行涉及多个效应量的荟萃分析。在一系列早期资助下,我们开发了一个荟萃分析程序,目前已在全球约 10,000 个机构中使用,其中包括数千家医院、大学和 FDA、CDC、NIH、WHO 等机构。我们的计划是将其扩展到报告多个效应大小的研究,并且不需要用户提供相关矩阵。
公共卫生相关性:只有当每项研究提供单一效应量时,才能使用当前一代的荟萃分析软件。该项目的目标是开发用于荟萃分析的软件,当一些(或全部)研究报告对多个结果、时间点或治疗的影响时,可以使用该软件。该软件不需要用户提供效果之间的相关矩阵。
项目成果
期刊论文数量(0)
专著数量(0)
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专利数量(0)
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Michael Borenstein其他文献
Michael Borenstein的其他文献
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{{ truncateString('Michael Borenstein', 18)}}的其他基金
Software for meta-analysis with correlated outcomes
用于具有相关结果的荟萃分析的软件
- 批准号:
8136379 - 财政年份:2011
- 资助金额:
$ 15.04万 - 项目类别:
Software for meta-analysis with correlated outcomes
用于具有相关结果的荟萃分析的软件
- 批准号:
8210976 - 财政年份:2011
- 资助金额:
$ 15.04万 - 项目类别:
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