Power Analysis for Meta Analysis

元分析的功效分析

• 批准号: 7340227
• 负责人: Michael Borenstein
• 金额: $ 45.08万
• 依托单位: BIOSTATISTICAL PROGRAMMING ASSOC, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7340227
• 关键词: Address; Adolescence; Analysis of Variance; Applications Grants; Attention; Behavioral; Books; Budgets; Case Study; Childhood; Clinical; Code; Complex; Computer Simulation; Computer software; Data; Databases; Decision Making; Development Plans; Discipline; Disease; Disease regression; Educational workshop; Effect Modifiers (Epidemiology); Ensure; Funding; Funding Agency; Goals; Grant; Graph; Hand; Heterogeneity; Humor; Intervention; Investments; Journals; Logic; Medicine; Mentors; Meta-Analysis; Methodology; Modeling; New Jersey; Numbers; Odds Ratio; Operative Surgical Procedures; Paper; Pharmaceutical Preparations; Play; Policies; Prevalence; Prevention; Process; Publishing; Range; Rate; Relative (related person); Reporting; Research; Research Personnel; Resources; Review, Systematic (PT); Risk; Role; Sample Size; Series; Social Sciences; Standards of Weights and Measures; Statistically Significant; Subgroup; Substance abuse problem; Testing; Text; Thinking; Time; Today; Trademark; United States National Institutes of Health; Update; Work; Writing; addiction; base; computer program; cost; cost effectiveness; design; handbook; hazard; inclusion criteria; indexing; novel; programs; size; social; software development; success; symposium; treatment effect

DESCRIPTION (provided by applicant): Meta-analysis plays a key role in setting policy and in planning new research. In the field of substance abuse prevention, meta-analyses have been used to determine the relative impact of competing treatments for addiction, to estimate prevalence of addiction-related diseases, to plan targeted interventions, to assess the cost-effectiveness of competing treatments, and to assist in planning more effective research. A systematic review and meta-analysis requires a substantial investment of time and resources. The time required is typically a year or more, and the cost can exceed a million dollars. Therefore, before embarking on a systematic review the researcher should conduct a power analysis to ensure that the review will have appropriate statistical power to yield a meaningful result. At present however, while the formulas for this kind of power analysis have been published, no mechanism exists for actually applying these formulas. The goal of this project is to develop software to compute power for meta-analysis. The program would be used to plan a new systematic review, to understand the implications of a completed review, to make decisions about updating a review with the inclusion of new studies, and to plan a set of primary studies that would be synthesized by meta-analysis. It will incorporate a sophisticated user interface to address the kinds of real-world issues that must be addressed in a power analysis. Meta-analysis plays a key role in setting policy and in planning new research. In the field of substance abuse prevention, for example, meta-analyses have been used to determine the relative impact of competing treatments for addiction. The goal of this project is to develop software to compute power for meta-analysis. The program would be used to plan a new systematic review and to understand the implications of a completed review.

描述（由申请人提供）：荟萃分析在制定政策和规划新研究方面发挥着关键作用。在药物滥用预防领域，荟萃分析已被用来确定竞争治疗对成瘾的相对影响，估计成瘾相关疾病的患病率，规划有针对性的干预措施，评估竞争治疗的成本效益，以及协助规划更有效的研究。系统评价和荟萃分析需要投入大量时间和资源。所需时间通常为一年或更长时间，成本可能超过一百万美元。因此，在开始系统评价之前，研究人员应进行功效分析，以确保评价具有适当的统计功效，从而产生有意义的结果。然而目前，虽然这种功率分析的公式已经公布，但不存在实际应用这些公式的机制。该项目的目标是开发软件来计算元分析的能力。该计划将用于计划一项新的系统审查，了解已完成审查的影响，做出有关更新审查以纳入新研究的决定，并计划一组将由荟萃分析综合的初步研究。分析。它将采用复杂的用户界面来解决功率分析中必须解决的各种现实问题。荟萃分析在制定政策和规划新研究方面发挥着关键作用。例如，在药物滥用预防领域，荟萃分析已被用来确定成瘾竞争治疗的相对影响。该项目的目标是开发软件来计算元分析的能力。该计划将用于计划新的系统审查并了解已完成审查的影响。