Tregs:sculpting a balance between protection and pathology during viral infection

Tregs：在病毒感染期间塑造保护与病理之间的平衡

• 批准号: 8090575
• 负责人: Thomas L. Cherpes
• 金额: $ 37.36万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-20 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8090575
• 关键词: Antibodies; Antigens; Biological Assay; Bioluminescence; Brain; Brefeldin A; Cells; Cessation of life; Characteristics; Congenic Mice; Data; Development; Disease; Encephalopathies; Enzyme-Linked Immunosorbent Assay; Equilibrium; Experimental Models; Flow Cytometry; Generations; Genital system; Genitalia; Human; Human Herpesvirus 2; Image; Immune response; Immunity; Immunotherapeutic agent; In Vitro; Infection; Infection Control; Inflammation; Inflammatory Response; Injury; Interferons; Interleukin-10; Interleukin-17; Invaded; Investigation; Knock-in Mouse; Knockout Mice; Laboratories; Lesion; Leukocytes; Lymphoid; Mediating; Methods; Modeling; Mouse Strains; Mus; Neuraxis; Pathologic; Pathology; Phenotype; Population; Prevention; Process; Production; Regulatory T-Lymphocyte; Simplexvirus; Specificity; Spinal Cord; T memory cell; T-Lymphocyte; Testing; Time; Tissues; Vagina; Viral; Virus; Virus Diseases; Virus Latency; abstracting; base; cell type; chemokine; cytokine; design; immunopathology; in vivo; lymph nodes; migration; mouse model; neutralizing antibody; pathogen; prevent; protective effect; receptor; response; therapeutic development

项目成果

Neonatal herpes simplex virus infection.

新生儿单纯疱疹病毒感染。

• 发表时间: 2012-12
• 影响因子: 1.5
• 作者: Cherpes, Thomas L;Matthews, Dean B;Maryak, Samantha A
• 通讯作者: Maryak, Samantha A

Dendritic cell activation and memory cell development are impaired among mice administered medroxyprogesterone acetate prior to mucosal herpes simplex virus type 1 infection.

在粘膜单纯疱疹病毒 1 型感染之前给予醋酸甲羟孕酮的小鼠，树突状细胞活化和记忆细胞发育受到损害。

• 发表时间: 2012-10-01
• 作者: Vicetti Miguel RD;Hendricks RL;Aguirre AJ;Melan MA;Harvey SA;Terry-Allison T;St Leger AJ;Thomson AW;Cherpes TL
• 通讯作者: Cherpes TL