Molecular, Structural & Clinical Aspects of Vitamin K-Dependent Proteins

分子、结构

• 批准号: 8199870
• 负责人: KATHLEEN Lucile BERKNER
• 金额: $ 2.15万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199870
• 关键词: Address; Area; Basic Science; Biochemical; Biochemistry; Biology; Blood Vessels; Blood coagulation; Cardiovascular Diseases; Cartilage; Cellular biology; Chairperson; Clinical; Cognitive Science; Collaborations; Communities; Degenerative polyarthritis; Development; Diabetes Mellitus; Dietary Factors; Discipline; Drug Kinetics; Endocrinology; Energy Metabolism; Ensure; Enzymatic Biochemistry; Future; Genetic; Genetic Polymorphism; Geriatrics; Goals; Health; Hemostatic function; Hormonal; International; Knowledge; Metabolic; Metabolism; Mission; Molecular; Nature; Nervous System Physiology; Oral; Osteocalcin; Physiological; Proteins; Public Health; Research; Research Personnel; Resistance; Role; Scientific Societies; Scientist; Structure-Activity Relationship; Therapeutic; Time; Tissues; Translational Research; Vascular calcification; Vitamin K; base; burden of illness; clinical application; dietary requirement; experience; gamma-glutamyl carboxylase; innovation; interdisciplinary approach; meetings; multidisciplinary; novel; nutrition; posters; prevent; programs; response; skeletal; skeletal tissue; symposium; vitamin K epoxide reductase

DESCRIPTION (provided by applicant): Vitamin K (VK) was discovered for its role in hemostasis, and requirements were historically based on the amount required for normal blood coagulation. In the past, the cohesiveness of the VK field was largely maintained by the focus on hemostasis. However, the field of VK now extends beyond this focus and is actively being studied across highly diverse disciplines by investigators new to the VK field. Scientific interactions have become increasingly challenging because VK biology is no longer represented by a single scientific society. The 2011 FASEB Summer Conference on "Molecular, Structural & Clinical Aspects of VK & VK-Dependent Proteins" is significant to the field because it is the only national and/or international conference dedicated to the study of VK biology. The overall objective of this conference is to provide a forum for the exchange of new knowledge about VK that spans from basic research to a wide variety of clinical applications. In recognition of this unique and highly disciplinary theme, our overarching conference goals are to: (1) Feature recognized multidisciplinary experts covering topics related to VK; (2) Discuss major advances in the field among young and experienced investigators, including those who are based in disciplines not traditionally associated with the VK community; and (3) Ensure a continued influx of new ideas and new investigators. To achieve this, we have created a program composed of many speakers who will be interacting with the VK community for the first time. We have also incorporated multiple opportunities for the interaction of graduate and post-graduate trainees and junior scientists with established investigators to promote a new cadre of investigators in the field of VK. The scientific problems to be discussed at the 2011 conference reflect this translational nature of VK biology: (1) Evolve the understanding of the VK-dependent carboxylase, and the VK epoxide reductase (VKOR); (2) Integrate the metabolic roles of newly discovered multiple VK-dependent proteins with important new findings regarding VK action in skeletal tissue, cartilage, and vascular tissues; (3) Evaluate the new developments that suggest emerging roles for VK and VK- dependent proteins in optimal functioning of the nervous system; and (4) Advance our current knowledge on VK metabolism used to formulate dietary requirements with recent findings in enzymology and pharmacokinetics. This conference is innovative because it will provide discussion on new linkages and roles of VK by drawing on the multi-disciplinary expertise of confirmed chairpersons and speakers in the fields of cell biology, biochemistry, cognitive psychology, and nutrition, and will facilitate new collaborations and areas of novel research. PUBLIC HEALTH RELEVANCE: The proposal to support the 2011 FASEB Summer Vitamin K (VK) conference is relevant to public health because it will promote interaction and future translational research collaborations to further our understanding of the emerging roles of VK in the promotion of skeletal health, and preventing vascular calcification and other health-related responses that may be associated with inadequate VK status. Thus, the proposed research is relevant to the NIH's mission to develop the identification of modifiable dietary factors that will help reduce the burden of diseases, such as cardiovascular disease, diabetes, and osteoarthritis.

描述（由申请人提供）：维生素 K (VK) 因其止血作用而被发现，历史上其需求量是基于正常凝血所需的量。过去，VK领域的凝聚力很大程度上是通过注重止血来维持的。然而，VK 领域现在已经超出了这一重点，新进入 VK 领域的研究人员正在积极跨高度多样化的学科进行研究。由于 VK 生物学不再由单一科学协会代表，科学互动变得越来越具有挑战性。 2011 年 FASEB 夏季会议“VK 和 VK 依赖性蛋白的分子、结构和临床方面”对该领域具有重要意义，因为它是唯一致力于研究 VK 生物学的国家和/或国际会议。本次会议的总体目标是提供一个交流 VK 新知识的论坛，涵盖从基础研究到各种临床应用的领域。认识到这一独特且高度学科化的主题，我们的总体会议目标是： (1) 邀请涵盖 VK 相关主题的公认多学科专家； (2) 讨论年轻和经验丰富的研究人员在该领域的重大进展，包括那些传统上与 VK 社区不相关的学科的研究人员； (3) 确保新想法和新研究者的不断涌入。为了实现这一目标，我们创建了一个由许多演讲者组成的计划，他们将首次与 VK 社区互动。我们还为研究生和研究生实习生以及初级科学家与现有研究人员的互动提供了多种机会，以培养 VK 领域的新研究人员队伍。 2011年会议将讨论的科学问题反映了VK生物学的这种转化性质：（1）发展对VK依赖性羧化酶和VK环氧化物还原酶（VKOR）的理解； (2) 将新发现的多种VK依赖性蛋白的代谢作用与有关骨骼组织、软骨和血管组织中VK作用的重要新发现相结合； (3) 评估表明 VK 和 VK 依赖性蛋白在神经系统最佳功能中的新作用的新进展； (4) 利用酶学和药代动力学的最新发现，推进我们目前关于 VK 代谢的知识，用于制定饮食要求。本次会议具有创新性，因为它将利用细胞生物学、生物化学、认知心理学和营养学领域已确认的主席和发言人的多学科专业知识，讨论 VK 的新联系和作用，并将促进新的合作和新颖的研究领域。 公共健康相关性：支持 2011 年 FASEB 夏季维生素 K (VK) 会议的提案与公共健康相关，因为它将促进互动和未来的转化研究合作，以进一步了解 VK 在促进骨骼健康方面的新兴作用，预防血管钙化和其他可能与 VK 状态不足有关的健康相关反应。因此，拟议的研究与美国国立卫生研究院的使命相关，该使命是确定可改变的饮食因素，这将有助于减轻心血管疾病、糖尿病和骨关节炎等疾病的负担。