STRUCTURAL CHARACTERIZATION OF A NOVEL LOW-SPIN ALKYLPEROXO-IRON(III) COMPLEX

新型低自旋烷基过氧铁(III)络合物的结构表征

• 批准号: 8170050
• 负责人: James E. Penner-Hahn
• 金额: $ 0.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170050
• 关键词: Complex; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Heme; Institution; Iron; Ligands; Ligation; Measurement; Peroxides; Research; Research Personnel; Resources; Role; Site; Source; Structure; United States National Institutes of Health; novel; oxidation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Goldberg an co-workers have recently prepared a novel low-spin non-heme peroxo complex(Krishnamurthy et al., in press). Vibrational spectra for the complex confirm the presence of an ironbound peroxide with unusually weak Fe-O and O-O bonsd, and UV-visible spectra suggest that the Fe oxidation state is best described as Fe(III). These measurements are unable to define the Fe ligation. In order to define the structure of the complex, and thus establish the understand its role as a mimic for bioinorganic sites, we need to determine whether a pendant thiolate ligand remains coordinated to the Fe. We will use EXAFS to define this structure.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 Goldberg 及其同事最近制备了一种新型低自旋非血红素过氧复合物（Krishnamurthy 等人，出版中）。该配合物的振动光谱证实了铁结合过氧化物的存在，该过氧化物具有异常弱的 Fe-O 和 O-O 键，并且紫外-可见光谱表明 Fe 氧化态最好描述为 Fe(III)。这些测量无法定义 Fe 连接。为了定义配合物的结构，从而了解其作为生物无机位点模拟物的作用，我们需要确定硫醇盐配体是否仍与 Fe 配位。我们将使用 EXAFS 来定义这个结构。