B CELL MEMORY

B细胞记忆

• 批准号: 8172441
• 负责人: JOSHY JACOB
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172441
• 关键词: Antibodies; Antigen-Antibody Complex; Antigens; B-Lymphocytes; Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Humoral Immunities; Immune response; Immune system; Immunologic Memory; Institution; Kinetics; Life; Memory; Memory B-Lymphocyte; Production; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Work; in vivo; pathogen; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Immunological memory is a hallmark of the vertebrate immune system. The first antigenic exposure leads to a slow and modest immune response while repeat exposure, even many years later, leads to a rapid and exaggerated response that is 2-3 orders of magnitude greater than the primary. In the case of humoral immunity, the increased efficacy of recall responses is due to the production of amplified levels of antigen-specific antibody, as well as the accelerated kinetics of their production. Current dogma suggests that this is due to selective activation of long-lived antigen-specific memory B cells. A downside of restricting secondary responses solely to memory cells is that the repertoire of the memory B cell pool remains static while pathogens continue to evolve. Here we are working to determine whether during secondary responses na¿ve, antigen-specific B cells participate alongside memory cells. We are showing that immune complexes formed in vivo between the antigen and pre-existing antibodies from the primary response, activate these naive B cells, inducing them to respond with accelerated kinetics and increased magnitude. The continued recruitment of new B cell clones following each antigenic exposure enables the immune system to stay abreast of rapidly changing pathogens.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 对于中心来说，它不一定是研究者的机构。 免疫记忆是脊椎动物免疫系统的一个标志，第一次抗原暴露会导致缓慢而温和的免疫反应，而重复暴露，甚至多年后，会导致快速而夸张的反应，比第一次接触大2-3个数量级。在体液免疫的情况下，记忆反应的功效增加是由于抗原特异性抗体的产生，以及其产生的加速动力学，目前的教条表明这是由于选择性激活。长寿的抗原特异性记忆 B 细胞。 仅将次级反应限制于记忆细胞的一个缺点是，当病原体继续进化时，记忆 B 细胞库的所有功能都保持不变。在这里，我们正在努力确定次级反应期间是否会发生变化。 ve，我们发现抗原特异性 B 细胞与记忆细胞一起参与体内抗原和初次反应中预先存在的抗体之间形成的免疫复合物，激活这些初始 B 细胞，诱导它们以加速的动力学和增加的幅度进行反应。每次抗原暴露后，新的 B 细胞克隆不断招募，使免疫系统能够跟上快速变化的病原体。