Craniofacial Morphogenesis and Tissue Regeneration Gordon Research Conference

颅面形态发生和组织再生戈登研究会议

• 批准号: 7905235
• 负责人: Paul Trainor
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905235
• 关键词: Accounting; Address; Animal Model; Area; Biology; Budgets; Cell Communication; Communities; Congenital Abnormality; Connective Tissue; Craniofacial Abnormalities; Development; Disease; Evolution; Face; Genetic; Goals; Head; Health; Healthcare; Infant Mortality; International; Mediating; Mission; Molecular; Morphogenesis; National Institute of Dental and Craniofacial Research; Natural regeneration; Neural Crest Cell; Prevention; Request for Proposals; Research; Research Personnel; Schedule; Series; Signal Pathway; Strategic Planning; Syndrome; Therapeutic; Tissue Engineering; Tissues; Wound Healing; craniofacial; genome wide association study; human disease; improved; innovation; malformation; meetings; novel; planetary Atmosphere; posters; prevent; programs; public health relevance; regenerative; repaired; skeletal; stem cell biology; symposium; tissue regeneration

DESCRIPTION (provided by applicant): Craniofacial abnormalities account for approximately one third of all congenital birth defects, are a major cause of infant mortality and dramatically impact upon national health care budgets. This proposal requests support for three biannual international meetings on Craniofacial Development and Tissue Regeneration as part of the Gordon Conference Research Series. The significance of this application is that it supports the conference that has become the pre-eminent meeting for the craniofacial community. The broad and long-term goal of these craniofacial GRC meetings is to advance our understanding of the fundamental mechanisms underlying normal craniofacial development, disease and evolution upon which novel avenues for prevention and repair can be developed to manage and treat congenital craniofacial birth defects. The specific aim of this application is to bring together leading investigators to present cutting-edge research on the molecular, cellular and genetic aspects of craniofacial development, evolution, disease and regeneration. More specifically, the Craniofacial GRC meetings will convene approximately 42 speakers representing critical areas of craniofacial development and tissue regeneration. The program will consist of 8 sessions that encompass, neural crest cells and placodes, development of, and interactions between skeletal and connective tissues, signaling pathways mediating cell communication, animal models and genome wide association studies of human disease, advances in regenerative stem cell biology and replacement of craniofacial tissues through tissue engineering. The collegial atmosphere of this Conference together with scheduled opportunities for informal gatherings and poster presentations provides numerous opportunities for interactive discussion, which focuses the field on the many unanswered questions and challenges within craniofacial biology. This proposal addresses a number of the missions and aims of the National Institute for Dental and Craniofacial Research's strategic plan by promoting novel and innovative research avenues for improving critical health issues in craniofacial development as well as preventing congenital craniofacial malformation syndromes. PUBLIC HEALTH RELEVANCE: Head and facial abnormalities account for approximately one third of all birth defects in new born babies, are a major cause of infant mortality and dramatically impact upon national health care budgets. Comprehensive and well-coordinated treatments can provide satisfactory management of each head and facial birth defect. However, the results are rarely fully corrective. Hence considerable effort needs to be invested into developing therapeutic avenues of prevention and also developing better regenerative strategies for craniofacial tissue repair.

描述（由申请人提供）：颅面畸形约占所有先天性出生缺陷的三分之一，是婴儿死亡的主要原因，并对国家医疗保健预算产生巨大影响。该提案请求支持三场关于颅面发育和组织再生的国际会议，作为戈登会议研究系列的一部分。该应用程序的意义在于它支持了已成为颅面界杰出会议的会议。这些颅面 GRC 会议的广泛和长期目标是增进我们对正常颅面发育、疾病和进化的基本机制的理解，在此基础上可以开发新的预防和修复途径来管理和治疗先天性颅面出生缺陷。 该应用程序的具体目的是汇集领先的研究人员，展示颅面发育、进化、疾病和再生的分子、细胞和遗传方面的前沿研究。更具体地说，颅面 GRC 会议将召集约 42 名代表颅面发育和组织再生关键领域的发言人。该计划将由 8 个会议组成，其中包括神经嵴细胞和基板、骨骼和结缔组织的发育和相互作用、介导细胞通讯的信号通路、人类疾病的动物模型和全基因组关联研究、再生干细胞生物学的进展以及通过组织工程替代颅面组织。本次会议的学院氛围以及预定的非正式聚会和海报展示机会提供了许多互动讨论的机会，重点关注颅面生物学中许多未解答的问题和挑战。 该提案通过促进新颖和创新的研究途径来改善颅面发育中的关键健康问题以及预防先天性颅面畸形综合征，从而解决了国家牙科和颅面研究所战略计划的许多使命和目标。 公共卫生相关性：头部和面部畸形约占新生儿所有出生缺陷的三分之一，是婴儿死亡的主要原因，并对国家医疗保健预算产生巨大影响。全面且协调一致的治疗可以为每个头部和面部出生缺陷提供满意的治疗。然而，结果很少能完全纠正。因此，需要投入大量精力来开发预防的治疗途径，并开发更好的颅面组织修复再生策略。