2021 Neural Crest and Cranial Placodes GRC/GRS

2021 神经嵴和颅板 GRC/GRS

基本信息

批准号：
10765885
负责人：
Paul Trainor
金额：
$ 0.3万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10765885
关键词：
Acceleration Achievement Address Adrenal Glands Adult Anterior Pituitary Gland Biological Models Biology Biomedical Research Cancer Biology Cardiac Cardiac Myocytes Cartilage Cells Cephalic Childhood Solid Neoplasm Chromaffin Cells Ciliary Muscle Clinical Collaborations Communities Congenital Abnormality Congenital Disorders Connective Tissue Corneal Endothelium Craniofacial Abnormalities Data Dedications Defect Development Disease Ectoderm Education Educational workshop Embryonic Development Endocrine Enteral Epithelium Equilibrium Evolution Eye Face Feedback Fertility Fostering Gender Genomics Goals Head Heart Heart Septum Homeostasis Hour Individual International Labyrinth Malignant Neoplasms Mentors Mentorship Mesenchymal Modeling Morphogenesis Morphology Neoplasm Metastasis Neural Crest Neural Crest Cell Neuroglia Neurons Nose Odontoblasts Oral Organ Participant Pathogenesis Pattern Peripheral Physiological Pigments Population Postdoctoral Fellow Proteomics Regenerative Medicine Research Research Personnel Science Scientist Sense Organs Sensory Sensory Ganglia Sensory Receptors Skin Supporting Cell System Systems Biology Taste Buds Technology Time Tissue Engineering Tissues Tooth structure Trigeminal System Underrepresented Minority Visceral Woman Work bone career career networking cell type disability experience gastrointestinal graduate student human stem cells innovation insight lateral line lens meetings migration neoplastic cell nerve supply neural plate neurodevelopment neurotransmission novel novel strategies peer peer networks posters regenerative biology somatosensory stem cell biology stem cells supportive environment symposium technological innovation transcriptomics

项目摘要

PROJECT SUMMARY Neural crest cells and cranial placodes share evolutionary and embryological origins and are of fundamental importance to vertebrate development, evolution and disease. Together, they form the cranial sensory ganglia, but individually they each give rise to an incredibly diverse array of cell types and tissues. Neural crest cells form most of the bone, cartilage and connective tissue of the head and face, the dentine-producing odontoblasts of teeth, the ciliary muscles and corneal endothelium of the eye, cardiomyocytes and aorticopulmonary septum of the heart, chromaffin cells in the adrenal gland, pigment cells in the skin, all peripheral glia, peripheral autonomic and enteric neurons, and most peripheral somatosensory neurons. Placodes form the sensory receptors, afferent innervation and support cells of the paired peripheral sense organs (nose, inner ear, lateral line system), the lenses of the paired eyes, cranial somatosensory (trigeminal) neurons and visceral sensory (epibranchial) neurons that transmit a wide variety of information from the heart, gut and other visceral organs, as well as taste buds, and the endocrine adenohypophysis which is important for fertility and homeostasis. Neural crest cells and cranial placodes provide experimental paradigms for studying cell and tissue induction, stem cell multipotency, patterning, morphogenesis, invagination, epithelial-mesenchymal transition, migration and differentiation. Neural crest cells and placodes are synonymous with vertebrate evolution, and defects in their development underlie a broad range of birth defects and diseases including craniofacial malformations, cardiac and gastrointestinal anomalies, sensory deficits, abnormal physiological function and cancer. This GRC and GRS on Neural Crest Cells and Cranial Placodes brings together a diverse group of leading scientists working on all aspects of neural crest cell and placode biology. The conference offers the chance to present unpublished data and novel approaches, form new collaborations, mentor junior scientists, and build professional networks in a supportive environment. The goals of the conference are to accelerate the exchange of interdisciplinary advances across different model systems, to promote technological innovations in the field, and deepen our understanding of neural crest cells and cranial placodes at genomic, transcriptomic and proteomic levels. Recent advances in generating neural crest cell and placode derivatives from human stem cells have major implications for our understanding of vertebrate development and evolution, the pathogenesis of congenital disorders and the promise of tissue engineering in regenerative medicine.

项目概要神经嵴细胞和颅板具有共同的进化和胚胎学起源，并且具有基础性对脊椎动物发育、进化和疾病的重要性。它们一起形成颅感觉神经节，但它们各自产生了极其多样化的细胞类型和组织。神经嵴细胞形成头部和面部的大部分骨骼、软骨和结缔组织，产生牙本质牙齿的成牙本质细胞、眼睛的睫状肌和角膜内皮、心肌细胞和心脏的主动脉肺隔、肾上腺的嗜铬细胞、皮肤的色素细胞等等外周神经胶质细胞、外周自主神经和肠神经元以及大多数外周体感神经元。基板形成配对外周感觉的感觉受体、传入神经支配和支持细胞器官（鼻子、内耳、侧线系统）、配对眼睛的晶状体、颅骨体感（三叉神经）神经元和内脏感觉（上鳃）神经元传递来自心脏的各种信息，肠道和其他内脏器官，以及味蕾和内分泌腺垂体，这对于生育力和体内平衡。神经嵴细胞和颅板为研究细胞和组织诱导提供了实验范例，干细胞多能性、模式化、形态发生、内陷、上皮-间质转化、迁移和差异化。神经嵴细胞和基板是脊椎动物进化的代名词，并且缺陷它们的发育是一系列出生缺陷和疾病的基础，包括颅面畸形、心脏和胃肠道异常、感觉缺陷、生理功能异常和癌症。这个关于神经嵴细胞和颅板的 GRC 和 GRS 汇集了不同的领先团队科学家致力于神经嵴细胞和基板生物学的各个方面。会议提供了机会展示未发表的数据和新颖的方法，形成新的合作，指导初级科学家，并建立支持性环境中的专业网络。会议的目标是加快跨不同模型系统的跨学科进展交流，促进技术创新该领域，并加深我们对基因组、转录组学方面的神经嵴细胞和颅板的理解和蛋白质组水平。从人类生成神经嵴细胞和基板衍生物的最新进展干细胞对于我们理解脊椎动物的发育和进化具有重大意义先天性疾病的发病机制以及组织工程在再生医学中的前景。