2010 Thiol-based Redox Regulation & Signaling Gordon Research Conference

2010年硫醇基氧化还原法规

• 批准号: 7804202
• 负责人: LESLIE B POOLE
• 金额: $ 0.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7804202
• 关键词: Oxidation-Reduction; Regulation; Research; Signal Transduction; Sulfhydryl Compounds; base; symposium

DESCRIPTION (provided by applicant): This proposal requests support for a Gordon Research conference on Thiol-based Redox Regulation and Signaling to be held May 9-14, 2010 at Il Ciocco in Italy. The field of redox biology is key to the biomedical sciences as an increasing number of cellular functions and impairments are found linked to redox processes. Central to redox control are systems that utilize thiols to perform redox chemistry. Thiol-containing proteins are major antioxidants in cells and reversible oxidation of thiols in various phosphatases, kinases and transcription factors links thiol-based redox chemistry to phosphorylation-based signaling, apoptosis, gene regulation, cell cycle control and other processes and pathways. Dysregulation of thiol-based redox homeostasis has major implications for the onset and progression of cancer, cardiovascular diseases, and other complex diseases and is a significant component of the process of aging. This conference is in its third cycle after a two very successful meetings in the U.S. and Italy in 2006 and 2008. The chair and vice-chair for this meeting are a physician scientist and a basic researcher, respectively, and are representative of the biologists, chemists and clinicians working on varied aspects of the field. This conference provides a venue for the free exchange of ideas and methodologies (the latter often limits progress in this particular field). While the thematic area of the conference is broad-based, its relevance to cancer, cardiovascular diseases and aging is well represented programmatically. By bringing together investigators with varied expertise in biophysical methods, bioinformatics and animal model systems, with physicians focused on disease processes, the meeting is expected to further stimulate collaborations and catalyze scientific progress as has been exemplified by the successes of the previous meetings.

描述（由申请人提供）：本提案请求支持将于 2010 年 5 月 9 日至 14 日在意大利 Il Ciocco 举行的关于基于硫醇的氧化还原调节和信号传导的 Gordon Research 会议。氧化还原生物学领域是生物医学的关键，因为越来越多的细胞功能和损伤被发现与氧化还原过程有关。氧化还原控制的核心是利用硫醇进行氧化还原化学的系统。含硫醇的蛋白质是细胞中的主要抗氧化剂，各种磷酸酶、激酶和转录因子中硫醇的可逆氧化将基于硫醇的氧化还原化学与基于磷酸化的信号传导、细胞凋亡、基因调控、细胞周期控制和其他过程和途径联系起来。基于硫醇的氧化还原稳态失调对癌症、心血管疾病和其他复杂疾病的发生和进展具有重大影响，并且是衰老过程的重要组成部分。继 2006 年和 2008 年在美国和意大利举行了两次非常成功的会议之后，本次会议已进入第三届。本次会议的主席和副主席分别是一位医学科学家和一位基础研究员，他们是生物学家的代表，从事该领域各个方面工作的化学家和临床医生。这次会议提供了自由交流思想和方法的场所（后者通常限制了该特定领域的进展）。虽然会议的主题领域基础广泛，但其与癌症、心血管疾病和衰老的相关性在议程上得到了很好的体现。通过汇集在生物物理方法、生物信息学和动物模型系统方面具有不同专业知识的研究人员，以及专注于疾病过程的医生，这次会议预计将进一步促进合作并促进科学进步，正如之前会议的成功所证明的那样。