2012 Thiol-based Redox Regulation & Signaling GRC and GRS

2012年硫醇基氧化还原调节

基本信息

批准号：
8252744
负责人：
LESLIE B POOLE
金额：
$ 0.75万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-22 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8252744
关键词：
Address Aging Amino Acids Animal Model Antioxidants Apoptosis Regulation Gene Area Bioinformatics Biological Models Biology Cell Cycle Regulation Cell Proliferation Cell physiology Cells Chemicals Chemistry Clinical Collaborations Communities Complex Cysteine Development Disease Doctor of Philosophy Elements Environment European Exposure to Flavoring France Functional disorder Generations Homeostasis Human International Italy Lead Link Location Maine Malignant Neoplasms Methodology Methods Modification Molecular Molecular Carcinogenesis New England Nitrogen Outcome Oxidation-Reduction Oxidative Stress Oxygen Pathologic Processes Pathway interactions Phosphoric Monoester Hydrolases Phosphorylation Phosphotransferases Physicians Physiological Processes Physiology Process Property Proteins Reaction Reactive Oxygen Species Regulation Request for Applications Request for Proposals Research Research Personnel Schedule Scientist Signal Transduction Site Stress Sulfhydryl Compounds Sulfur Technology Therapeutic Work age related base college disulfide bond environmental agent environmental toxicology frontier graduate student improved interest meetings member oxidation protein folding protein function public health relevance success symposium transcription factor tumor progression

项目摘要

DESCRIPTION (provided by applicant) This proposal requests support for the Fourth Gordon Research Conference (and first associated Gordon Research Seminar) on Thiol-based Redox Regulation and signaling to be held at Bates College in Lewiston, Maine, from July 28th to August 3rd, 2012. The subtitle of this conference, "Molecular Underpinnings of Redox Regulation and Oxidative Stress," reflects the focus of the upcoming meeting on the interplay between regulation of protein function and fundamental cellular processes through redox modifications on thiols, and the dysregulation that ensues under environmental conditions that exacerbate oxidative stress. Thiol-containing proteins are major antioxidants in cells, and reversible oxidation of thiols in phosphatases, kinases and transcription factors links thiol-based redox chemistry to phosphorylation-based signaling, cell proliferation, apoptosis, gene regulation, cell cycle control and other processes and pathways. Dysregulation of thiol-based redox homeostasis, for example by exposure to environmental agents which promote the generation of excessive damaging reactive oxygen species, may impart an element of irreversibility to redox regulation and has major implications for the onset and progression of cancer and complex age-related diseases. This interdisciplinary conference is in its fourth cycle after three very successful meetings in the U.S. (2006) and Italy (2008 and 2010), and will provide, as it has in the past, an important venue for the free exchange of ideas and methodologies among the molecular biologists and toxicologists, chemists and clinicians working on various aspects of the field. While the thematic area of the conference is broad-based, its relevance to environmental stress, carcinogenesis and the molecular basis for normal human physiology and disease is enormous. By bringing together investigators with varied expertise in biophysical methods, bioinformatics and animal model systems, with clinical researchers and physicians focused on disease processes, the meeting is expected to further stimulate collaborations and catalyze scientific progress as has been exemplified by the successes of the previous meetings. Public Health Relevance: Many cellular functions rely on processes that involve changes in redox properties of particular molecules within the cell, and the dysregulation of these processes is a major component of the onset and progression of aging and cancer. One amino acid, cysteine (which contains a thiol group), serves as a molecular switch and is central to these redox changes, although very few molecular details of which redox changes occur during normal and pathological processes are known. This conference brings together chemists, molecular biologists and toxicologists, and clinicians to promote the sharing of different levels of understanding of thiol-dependent processes and enable therapeutic benefits to be gained from our improved understanding.

描述（由申请人提供）该提案请求支持将于 2012 年 7 月 28 日至 8 月 3 日在缅因州刘易斯顿贝茨学院举行的关于基于硫醇的氧化还原调节和信号传导的第四届戈登研究会议（以及第一次相关的戈登研究研讨会）。会议题为“氧化还原调节和氧化应激的分子基础”，反映了即将举行的会议的重点是通过氧化还原修饰调节蛋白质功能和基本细胞过程之间的相互作用。硫醇，以及在加剧氧化应激的环境条件下随之而来的失调。含硫醇的蛋白质是细胞中的主要抗氧化剂，磷酸酶、激酶和转录因子中硫醇的可逆氧化将基于硫醇的氧化还原化学与基于磷酸化的信号传导、细胞增殖、细胞凋亡、基因调控、细胞周期控制和其他过程和途径联系起来。基于硫醇的氧化还原稳态的失调，例如通过暴露于促进产生过量破坏性活性氧的环境因素，可能会给氧化还原调节带来不可逆性，并对癌症和复杂年龄的发生和进展产生重大影响。相关疾病。继在美国（2006 年）和意大利（2008 年和 2010 年）举行了三次非常成功的会议之后，本次跨学科会议已进入第四个周期，并将像过去一样，为各学科之间自由交流思想和方法论提供一个重要场所。从事该领域各个方面工作的分子生物学家、毒理学家、化学家和临床医生。虽然会议的主题领域基础广泛，但其与环境压力、致癌作用以及正常人类生理和疾病的分子基础的相关性是巨大的。通过汇集在生物物理方法、生物信息学和动物模型系统方面具有不同专业知识的研究人员，以及专注于疾病过程的临床研究人员和医生，此次会议预计将进一步促进合作并促进科学进步，正如之前会议的成功所证明的那样。公共健康相关性：许多细胞功能依赖于涉及细胞内特定分子氧化还原特性变化的过程，这些过程的失调是衰老和癌症发生和进展的主要组成部分。一种氨基酸，半胱氨酸（含有硫醇基），充当分子开关，并且是这些氧化还原变化的核心，尽管我们对正常和病理过程中发生氧化还原变化的分子细节知之甚少。这次会议汇集了化学家、分子生物学家和毒理学家以及临床医生，以促进分享对硫醇依赖性过程的不同层次的理解，并使我们能够从加深的理解中获得治疗益处。