2010 Biopolymers Gordon Research Conference

2010年生物聚合物戈登研究会议

• 批准号: 7903511
• 负责人: DOROTHY BECKETT
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7903511
• 关键词: Amyloid; Binding; Biological; Biological Process; Biomedical Research; Biopolymers; Birth; Cessation of life; Communities; Complex; DNA; Defect; Disease; Drug Delivery Systems; Engineering; Fostering; Funding Applicant; Gene Expression; Goals; Membrane Proteins; Metabolism; Minority; Molecular Machines; Nucleic Acids; Play; Problem Solving; Property; Proteins; RNA; Recording of previous events; Research; Role; Schedule; Science; Scientist; Signal Transduction; Structure; Students; Suggestion; System; Techniques; Therapeutic Agents; Time; Woman; chemical property; design; human disease; improved; interest; macromolecule; meetings; member; programs; protein structure; public health relevance; response; symposium

DESCRIPTION (provided by applicant): Funds are requested for partial support of the 2010 Biopolymers Gordon Research Conference. This conference has a long and distinguished history of serving the segment of the scientific community that is focused on understanding fundamental physical-chemical properties of biopolymers (proteins, RNA, DNA), including their structures, folding, dynamics, stability, and interactions. The 2010 Biopolymers GRC is particularly interested in supporting the participation of minorities and women. The broad goals of the conference are to improve our understanding of the fundamental properties of biopolymers and the relationship of these properties to their biological function. The specific aims of this meeting are to assemble leaders in the biopolymers field with junior scientists, postdocs and students in a five-day conference to discuss current approaches to elucidating the structures, function and folding of biopolymers and their complexes. The significance of the proposal is the unique role that the Biopolymers Gordon Conference plays in fostering interdisciplinary interactions among scientists who apply a breadth of techniques to understanding a number of distinct systems. Regular interdisciplinary meetings of this type inevitably support advances in science by promoting integration of distinct approaches to solving problems. Most importantly, the format of the Gordon Research Conference, in which much time is allotted to informal and formal discussion, is ideal for fostering the interactions that are critical precursors to interdisciplinary science. Furthermore, the Biopolymers GRC, by advancing understanding of the fundamental properties of biological macromolecules will directly benefit biomedical research across diverse fields. In choosing topics and speakers for the 2010 meeting, input was sought from members of science community. The organizers have also incorporated suggestions offered in response to the 2008 program. In addition to a keynote session, the 2010 schedule includes the following regular sessions: 1. RNA structure, folding and dynamics 2. Molecular Machines Acting on Nucleic Acids; 3. Binding, Allostery and Dynamics; 4. Proteins from Birth to Death; 5. Biopolymers by Design; 6. Membrane Proteins: Structure, Folding and Function; 7. Folding and Unfolding, Order and Disorder, and 8. Amyloid (Death by Misfolding). PUBLIC HEALTH RELEVANCE: Biopolymers (proteins, RNA, DNA) are central to biological processes including signal transduction, metabolism and gene expression. Since defects in biopolymers are implicated in many human diseases, they are drug targets and are increasingly utilized as therapeutic agents themselves. The 2010 Biopolymers Gordon Research Conference will feature discussion of recent advances in understanding the structure, stability and dynamics of biopolymers as well as engineering of biopolymers for new function.

描述（由申请人提供）： 请求资金用于部分支持 2010 年生物聚合物戈登研究会议。 本次会议有着悠久而杰出的服务科学界的历史，其重点是了解生物聚合物（蛋白质、RNA、DNA）的基本物理化学性质，包括其结构、折叠、动力学、稳定性和相互作用。 2010 年生物聚合物 GRC 特别关注支持少数群体和妇女的参与。 会议的主要目标是提高我们对生物聚合物的基本特性以及这些特性与其生物功能之间的关系的理解。 本次会议的具体目的是在为期五天的会议上聚集生物聚合物领域的领导者与初级科学家、博士后和学生，讨论目前阐明生物聚合物及其复合物的结构、功能和折叠的方法。 该提案的重要性在于生物聚合物戈登会议在促进科学家之间的跨学科互动方面发挥着独特的作用，这些科学家应用广泛的技术来理解许多不同的系统。 这种类型的定期跨学科会议不可避免地通过促进解决问题的不同方法的整合来支持科学的进步。 最重要的是，戈登研究会议的形式，其中分配了大量时间进行非正式和正式讨论，非常适合促进作为跨学科科学的重要先驱的互动。 此外，生物聚合物GRC通过增进对生物大分子基本特性的理解，将直接有利于各个领域的生物医学研究。 在选择 2010 年会议的主题和发言人时，征求了科学界成员的意见。 组织者还采纳了针对 2008 年计划提出的建议。 除了主题演讲之外，2010 年日程还包括以下常规会议： 1. RNA 结构、折叠和动力学 2. 作用于核酸的分子机器； 3. 结合、变构和动力学； 4.从出生到死亡的蛋白质； 5. 生物聚合物设计； 6. 膜蛋白：结构、折叠和功能； 7. 折叠和展开、有序和无序，以及 8. 淀粉样蛋白（错误折叠导致死亡）。 公共卫生相关性：生物聚合物（蛋白质、RNA、DNA）对于信号转导、新陈代谢和基因表达等生物过程至关重要。由于生物聚合物的缺陷与许多人类疾病有关，因此它们是药物靶标，并且本身越来越多地用作治疗剂。 2010 年生物聚合物戈登研究会议将重点讨论生物聚合物的结构、稳定性和动力学以及生物聚合物新功能工程方面的最新进展。