DRUG INDUCED ILLNESS IN THE ELDERLY: NSAIDS AS A MODEL

老年人因药物引起的疾病：非甾体抗炎药作为模型

• 批准号: 3078699
• 负责人: JERRY H GURWITZ
• 金额: $ 3.55万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1993-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3078699
• 关键词: aging; antihypertensive agents; antiinflammatory agents; arthritis; beta antiadrenergic agent; chlorothiazide; clinical trials; curriculum; decision making; diuretics; drug adverse effect; epidemiology; health care cost /financing; health care professional practice; human subject; kidney function; medical education; patient care management; pharmacology

The applicant, Dr. Jerry Gurwitz, proposes a coordinated program of research, education, and practice in geriatrics under the auspices of the Harvard Medical School Division on Aging. Dr. Jerry Avorn, Associate Professor in the Gerontology Division of the Harvard Department of Medicine, will be the applicant's sponsor. The research program will incorporate a multidimensional approach to systematically examine the problem of drug-induced illness in the elderly employing a single medication category, the nonsteroidal anti-inflammatory drugs (NSAIDs), as a model. The program will include three components: (1) a population-based pharmaco-epidemiologic investigation of the adverse effects of NSAIDs on antihypertensive control in the elderly; (2) a complementary randomized, controlled clinical study examining the NSA]ID/blood pressure interaction as well as renal effects of NSAIDs in a population of ambulatory elderly subjects; and (3) a direct application of the results of the pharmacoepidemiologic and clinical investigations to the study of clinical decision-making in the care of elderly patients. The educational component will include the development of an innovative curriculum in geriatric clinical pharmacology to be employed at all levels of medical education from medical school to continuing education programs for practicing physicians. Clinical activities will emphasize long-term care, and will include the development of a program for the education and training of medical house officers in this setting. The substantial research, educational, and clinical resources of the Harvard Division on Aging will be available to assure accomplishment of the goals set out in this application.

申请人杰里·古威茨（Jerry Gurwitz）博士提出了一个协调的计划 在老年医学的研究，教育和实践的主持下 哈佛医学院衰老部门。 杰里·沃恩博士， 哈佛老年医学副教授 医学系将是申请人的赞助商。 研究 程序将结合系统地进行多维方法 检查使用A的老年人中药物诱发的疾病问题 单一药物类别，非甾体类抗炎药 （NSAIDS），作为模型。 该程序将包括三个组件：（1） 基于人群的药物 - 不利的药学研究 NSAID对老年人降压控制的影响； （2）a 互补的随机，对照临床研究检查 NSA] ID/血压相互作用以及NSAID的肾脏影响 一群门诊老年人； （3）直接 药物ePIDEMIologic和临床结果的应用 调查研究临床决策的研究 老年患者。 教育部分将包括创新的发展 从事老年临床药理学课程 从医学院到继续教育的医学教育水平 实践医生的计划。 临床活动将强调 长期护理，并将包括开发计划 在这种情况下，医疗机构官员的教育和培训。 这 哈佛大学的大量研究，教育和临床资源 老龄化师将可以确保完成 在此应用程序中设定的目标。