Risk Factors for Atherosclerosis among Patients with Heart Failure in Kenya

肯尼亚心力衰竭患者动脉粥样硬化的危险因素

• 批准号: 7760311
• 负责人: Gerald Samuel Bloomfield
• 金额: $ 12.7万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7760311
• 关键词: Africa South of the Sahara; African; Albumins; American; Anemia; Ankle; Apolipoproteins B; Atherosclerosis; Biological Assay; Biometry; Blood Pressure; Body mass index; C-reactive protein; Cardiology; Cardiovascular Diseases; Cholesterol; Chronic; Clinic; Clinical; Clinical Research; Clinical Trials; Clinical assessments; Data; Degenerative Disorder; Development Plans; Diabetes Mellitus; Diastolic blood pressure; Disadvantaged; Echocardiography; Economics; Educational Curriculum; Epidemiology; Etiology; Future; Glycosylated Hemoglobin; HIV Seropositivity; Health; Heart failure; High Density Lipoproteins; Human; Hypertension; Indiana; Institutes; International; Kenya; Lead; Left Ventricular Hypertrophy; Lipoprotein (a); Low-Density Lipoproteins; Manuscripts; Measures; Mentors; Mentorship; Methods; Motion; Myocardial Infarction; Myocardial Ischemia; Patients; Peripheral arterial disease; Prevalence; Prevention strategy; Primary Prevention; Public Health Schools; Recording of previous events; Registries; Research; Research Design; Research Infrastructure; Research Institute; Research Personnel; Research Training; Risk Factors; Secondary Prevention; Serological; Structure; Taxonomy; Tobacco smoking; Training; Training Programs; Training and Education; Triglycerides; Universities; Waist-Hip Ratio; abstracting; base; career development; case control; cost; design; experience; global health; improved; indexing; interest; medical schools; member; modifiable risk; patient oriented research; patient population; programs; prospective; symposium

DESCRIPTION (provided by applicant): Dr. Gerald Bloomfield is a cardiology fellow-in-training at Duke University. The candidate's long-term interest is to become a clinical researcher in the epidemiology and treatment of chronic cardiovascular disease (CVD) in the developing world, thereby improving the health of the disadvantaged using primary and secondary prevention methods. The proposed career development plan incorporates a multi-disciplinary program designed to provide an intense, closely mentored, patient-oriented research experience in association with a comprehensively structured didactic curriculum in biostatistics and epidemiology. Under the mentorship of Dr. John A. Bartlett (Duke Global Health Institute), Dr. Bob Harrington (Duke Clinical Research Institute, DCRI), Dr. Fabian Esamai (Moi University School of Medicine, Kenya) and Dr. Thomas Gaziano (Harvard University School of Public Health), Dr. Bloomfield will employ a case-control research design in Kenyan patients with and without heart failure (HF). Using modern echocardiography, serologic assays and clinical assessments, our specific aims are to identify and describe the taxonomies of heart failure in a Kenyan Tertiary Referral University clinic with special emphasis on ischemic heart disease, to describe the prevalence of subclinical atherosclerosis among patients with heart failure and to describe the prevalence of modifiable and non-modifiable risk factors for atherosclerosis among patients with heart failure. By spending one year with the Moi University School of Medicine in Kenya performing this project, we hope to collect pilot data on the burden of atherosclerosis among patients with heart failure; thereby informing hypotheses for larger prospective, regionally-relevant analyses in the future. Dr Bloomfield will also mentor aspiring Kenyan clinical researchers and facilitate portions of a clinical research training program. The candidate will have at his disposal the infrastructure, patient population and statistical support of the American/Sub Saharan African Network for Training and Education (ASANTE) consortium based in Eldoret, Kenya whose members include Moi University, Indiana University, Brown University and Duke University. In years 2 and beyond, Dr. Bloomfield will take part in the DCRI clinical research training program, experience first-hand the featutes of conducting international clinical trials, attend weekly research conferences, present abstracts at national.conferences and draft manuscripts. PUBLIC HEALTH RELEVANCE: As the landscape of CVD in Sub-Saharan Africa (SSA) shifts from communicable to chronic, degenerative diseases, the economic and human costs will significantly challenge the region. Understanding the modern etiologies of HF and prevalence of atherosclerosis in SSA are important so that we can implement relevant preventive strategies, create locally pertinent long-term registries and appropriately train a cadre of Kenyan clinician investigators to lead this effort in the future.

描述（由申请人提供）：Gerald Bloomfield 博士是杜克大学心脏病学实习研究员。候选人的长期兴趣是成为发展中国家慢性心血管疾病（CVD）流行病学和治疗的临床研究员，从而利用一级和二级预防方法改善弱势群体的健康。拟议的职业发展计划包含一个多学科计划，旨在提供密集、密切指导、以患者为导向的研究经验，并结合生物统计学和流行病学方面全面结构化的教学课程。在 John A. Bartlett 博士（杜克大学全球健康研究所）、Bob Harrington 博士（杜克大学临床研究所，DCRI）、Fabian Esamai 博士（肯尼亚莫伊大学医学院）和 Thomas Gaziano 博士（哈佛大学）的指导下布卢姆菲尔德博士将在肯尼亚患有和不患有心力衰竭（HF）的患者中采用病例对照研究设计。使用现代超声心动图、血清学检测和临床评估，我们的具体目标是在肯尼亚第三转诊大学诊所中识别和描述心力衰竭的分类，特别强调缺血性心脏病，以描述心力衰竭患者中亚临床动脉粥样硬化的患病率并描述心力衰竭患者中动脉粥样硬化可改变和不可改变危险因素的患病率。通过与肯尼亚莫伊大学医学院合作开展这一项目一年，我们希望收集有关心力衰竭患者动脉粥样硬化负担的试点数据；从而为未来更大规模的前瞻性、区域相关分析提供假设。布卢姆菲尔德博士还将指导有抱负的肯尼亚临床研究人员，并促进部分临床研究培训计划。候选人将拥有位于肯尼亚埃尔多雷特的美国/撒哈拉以南非洲培训和教育网络 (ASANTE) 联盟的基础设施、患者群体和统计支持，该联盟的成员包括莫伊大学、印第安纳大学、布朗大学和杜克大学。在第二年及以后，布卢姆菲尔德博士将参加 DCRI 临床研究培训计划，亲身体验进行国际临床试验的特点，参加每周的研究会议，在国家会议上发表摘要并起草手稿。 公共卫生相关性：随着撒哈拉以南非洲 (SSA) 的 CVD 形势从传染性疾病转变为慢性退行性疾病，经济和人力成本将对该地区构成重大挑战。了解心力衰竭的现代病因和 SSA 中动脉粥样硬化的患病率非常重要，以便我们能够实施相关的预防策略，建立与当地相关的长期登记册，并适当培训肯尼亚临床研究人员骨干，以领导未来的这项工作。