Risk Factors for Atherosclerosis among Patients with Heart Failure in Kenya

肯尼亚心力衰竭患者动脉粥样硬化的危险因素

基本信息

批准号：
8703189
负责人：
Gerald Samuel Bloomfield
金额：
$ 11.33万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-16 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8703189
关键词：
Africa South of the Sahara African Albumins American Anemia Ankle Apolipoproteins A Apolipoproteins B Atherosclerosis Biological Assay Biometry Blood Pressure Body mass index C-reactive protein Cardiology Cardiovascular Diseases Cholesterol Chronic Clinic Clinical Clinical Research Clinical Trials Clinical assessments Data Degenerative Disorder Development Plans Diabetes Mellitus Diastolic blood pressure Disadvantaged Echocardiography Economics Epidemiology Etiology Future Glycosylated Hemoglobin HIV Seropositivity Health Heart failure High Density Lipoproteins Human Hypertension Indiana Institutes Instruction International Kenya Lead Left Ventricular Hypertrophy Lipoprotein (a)Low-Density Lipoproteins Manuscripts Measures Mentors Mentorship Methods Motion Myocardial Infarction Myocardial Ischemia Patients Peripheral arterial disease Prevalence Prevention strategy Primary Prevention Public Health Schools Recording of previous events Registries Research Research Design Research Infrastructure Research Institute Research Personnel Research Training Risk Factors Secondary Prevention Serological Structure Taxonomy Tobacco smoking Training Training Programs Training and Education Triglycerides Universities Waist-Hip Ratio abstracting base career development case control cost design didactic education experience global health improved indexing interest medical schools member modifiable risk patient oriented research patient population programs prospective symposium

项目摘要

PROJECT SUMMARY (See instructions): Dr. Gerald Bloomfield is a cardiology fellow-in-training at Duke University. The candidate's long-term interest is to become a clinical researcher in the epidemiology and treatment of chronic cardiovascular disease (CVD) in the developing world, thereby improving the health of the disadvantaged using primary and secondary prevention methods. The proposed career development plan incorporates a multi-disciplinary program designed to provide an intense, closely mentored, patient-oriented research experience in association with a comprehensively structured didactic curriculum in biostatistics and epidemiology. Under the mentorship of Dr. John A. Bartlett (Duke Global Health Institute), Dr. Bob Harrington (Duke Clinical Research Institute, DCRI), Dr. Fabian Esamai (Moi Univei-sity School of Medicine, Kenya) and Dr. Thomas Gaziano (Harvard University School of Public Health), Dr. Bloomfield will employ a case-control research design in Kenyan patients with and without heart failure (HF). Using modern echocardiography, serologic assays and clinical assessments, our specific aims are to identify and describe the taxonomies of heart failure in a Kenyan Tertiary Referral University clinic with special emphasis on ischemic heart disease, to describe the prevalence of subclinical atherosclerosis among patients with heart failure and to describe the prevalence of modifiable and non-modifiable risk factors for atherosclerosis among patients with heart failure. By spending one year with the Moi University School of Medicine in Kenya performing this project, we hope to collect pilot data on the burden of atherosclerosis among patients with heart failure; thereby informing hypotheses for larger prospective, regionally-relevant analyses in the future. Dr Bloomfield will also mentor aspiring Kenyan clinical researchers and facilitate portions of a clinical research training program. The candidate will have at his disposal the infrastructure, patient population and statistical support of the American/Sub Saharan African Network for Training and Education (ASANTE) consortium based in Eldoret, Kenya whose members include Moi University, Indiana University, Brown University and Duke University. In years 2 and beyond, Dr. Bloomfield will take part in the DCRI clinical research training program, experience first-hand the featutes of conducting international clinical trials, attend weekly research conferences, present abstracts at national.conferences and draft manuscripts.

项目摘要（参见说明）：杰拉尔德·布卢姆菲尔德 (Gerald Bloomfield) 博士是杜克大学心脏病学实习研究员。候选人的长期兴趣是成为慢性病流行病学和治疗的临床研究员发展中国家的心血管疾病（CVD），从而改善人们的健康使用一级和二级预防方法处于不利地位。拟议的职业发展计划包含一个多学科计划，旨在提供紧张的、密切指导的、以患者为中心的研究经验与全面结构化的教学相结合生物统计学和流行病学课程。在 John A. Bartlett 博士（杜克大学）的指导下全球健康研究所）、Bob Harrington 博士（杜克临床研究所、DCRI）、Fabian 博士 Esamai（肯尼亚莫伊大学医学院）和 Thomas Gaziano 博士（哈佛大学）公共卫生学院），布卢姆菲尔德博士将采用肯尼亚语的病例对照研究设计患有或不患有心力衰竭（HF）的患者。使用现代超声心动图、血清学检测和临床评估，我们的具体目标是确定和描述心力衰竭的分类法肯尼亚第三转诊大学诊所，特别重视缺血性心脏病，描述心力衰竭患者中亚临床动脉粥样硬化的患病率，并描述动脉粥样硬化可改变和不可改变危险因素的患病率心力衰竭患者。在肯尼亚莫伊大学医学院学习一年执行这个项目，我们希望收集有关患者动脉粥样硬化负担的试点数据患有心力衰竭；从而为更大规模的前瞻性、区域相关分析提供假设未来。布卢姆菲尔德博士还将指导有抱负的肯尼亚临床研究人员并促进部分临床研究培训计划。候选人将拥有可供他使用的基础设施，患者群体和美国/撒哈拉以南非洲培训网络的统计支持和教育 (ASANTE) 联盟，总部位于肯尼亚埃尔多雷特，其成员包括莫伊大学、印第安纳大学、布朗大学和杜克大学。在第二年及以后，布卢姆菲尔德博士将参加DCRI临床研究培训项目，亲身体验进行国际临床试验，参加每周研究会议，在以下网站发表摘要全国会议和手稿草稿。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Heart failure in sub-Saharan Africa.

撒哈拉以南非洲地区的心力衰竭。

DOI：
发表时间：
2013-05
期刊：
影响因子：
1.9
作者：
Bloomfield, Gerald S;Barasa, Felix A;Doll, Jacob A;Velazquez, Eric J
通讯作者：
Velazquez, Eric J

Human Immunodeficiency Virus and Heart Failure in Low- and Middle-Income Countries.

低收入和中等收入国家的人类免疫缺陷病毒和心力衰竭。

DOI：
发表时间：
2015-08
期刊：
影响因子：
0
作者：
Bloomfield, Gerald S;Alenezi, Fawaz;Barasa, Felix A;Lumsden, Rebecca;Mayosi, Bongani M;Velazquez, Eric J
通讯作者：
Velazquez, Eric J

A practical guide to multimodality imaging of transcatheter aortic valve replacement.

经导管主动脉瓣置换术多模态成像实用指南。

DOI：
发表时间：
2012-04
期刊：
影响因子：
0
作者：
Bloomfield, Gerald S;Gillam, Linda D;Hahn, Rebecca T;Kapadia, Samir;Leipsic, Jonathon;Lerakis, Stamatios;Tuzcu, Murat;Douglas, Pamela S
通讯作者：
Douglas, Pamela S

Multiple cardiovascular risk factors in Kenya: evidence from a health and demographic surveillance system using the WHO STEPwise approach to chronic disease risk factor surveillance.

肯尼亚的多种心血管危险因素：来自使用世界卫生组织逐步方法进行慢性病危险因素监测的健康和人口监测系统的证据。

DOI：
发表时间：
2013-09
期刊：
影响因子：
0
作者：
Bloomfield, Gerald S;Mwangi, Ann;Chege, Patrick;Simiyu, Chrispinus J;Aswa, Daniel F;Odhiambo, David;Obala, Andrew A;Ayuo, Paul;Khwa
通讯作者：
Khwa