Non-Invasive Measurements of Brown Adipose Tissues

棕色脂肪组织的非侵入性测量

• 批准号: 8044246
• 负责人: FRED STERZER
• 金额: $ 19.6万
• 依托单位: MMTC, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8044246
• 关键词: Non; Invasive; Measurements; Brown; Adipose

DESCRIPTION (provided by applicant): Progress in understanding the function of human brown adipose tissues [HBAT] and hopefully eventually being able to use this improved understanding to help control the current obesity epidemic will require the development of "tools and methods capable of measuring the mass of BAT in human populations and to measure metabolic activity of HBAT". The aim of the proposed research program is to meet these needs by developing user-friendly, non-invasive, and completely safe microwave radiometers specifically designed for HBAT research. The radiometers will be based on handheld, self-calibrating, digital radiometers developed previously by MMTC, Inc. under sponsorship of NIH. They will be designed to be capable of operating in either passive or active modes that can respectively measure the metabolic activity and mass of HBAT and meet all applicable FDA safety standards for medical devices. Application will be made to the FDA to obtain approval for these radiometers. Radiometer antennas with fixed and variable depth of penetration into tissues will be fabricated and tested in tissue equivalent phantoms. The measured radiometric temperatures and locations of heated deep-seated simulated HBAT will be cataloged for a variety of phantom configurations and various antennas and all data will be assembled in a form that aids in the interpretation of passive and active microwave radiometric measurements of HBAT. After successful completion of the testing of the radiometers in phantoms, the dual- mode radiometers will be tested on 10 healthy young volunteers on whom FDG PET/CT scans will be performed to verify uptake of the radioactive tracers in activated and non- activated HBAT states induced by hot/cold environments. The tests will be performed at Johns Hopkins University School of Medicine and supervised by Richard L. Wahl, M.D., F.A.C.R., Professor of Radiology and Oncology and Henry N. Wagner, Jr. Professor of Nuclear Medicine who has done pioneering work on HBAT using PET/CT scans. The ultimate goal of this work is to replace the radiation and cost of PET/CT with a safe, faster, and cheaper microwave radiometry method. Only by directly comparing the relative gold standard of FDG in the stimulated and non-stimulated HBAT states in humans with the new method can we determine the radiometry operating characteristics in man. PUBLIC HEALTH RELEVANCE: The proposed program is for the development of a medical device designed to aid healthcare professionals in gaining a better understanding of the role of human brown fat in fighting obesity. This better understanding can be expected to lead to improved methods for treating obesity, the current epidemic of obesity being responsible for many sicknesses and early deaths.

描述（由申请人提供）：在理解人类棕色脂肪组织 [HBAT] 功能方面取得进展，并希望最终能够利用这种改进的理解来帮助控制当前的肥胖流行病，将需要开发“能够测量棕色脂肪组织（HBAT）功能的工具和方法”。人群中 BAT 的质量并测量 HBAT 的代谢活性”。拟议研究计划的目的是通过开发专为 HBAT 研究设计的用户友好、非侵入性且完全安全的微波辐射计来满足这些需求。这些辐射计将基于 MMTC, Inc. 先前在 NIH 的赞助下开发的手持式自校准数字辐射计。它们将被设计为能够在被动或主动模式下运行，分别测量 HBAT 的代谢活性和质量，并满足 FDA 所有适用的医疗器械安全标准。将向 FDA 提出申请以获得这些辐射计的批准。将在组织等效体模中制造和测试具有固定和可变的组织穿透深度的辐射计天线。测量的加热深埋模拟 HBAT 的辐射温度和位置将针对各种模型配置和各种天线进行编目，所有数据将以有助于解释 HBAT 的无源和有源微波辐射测量的形式进行组装。成功完成体模中辐射计的测试后，将对 10 名健康的年轻志愿者进行双模辐射计测试，并对这些志愿者进行 FDG PET/CT 扫描，以验证激活和非激活 HBAT 状态下放射性示踪剂的吸收由热/冷环境引起。这些测试将在约翰·霍普金斯大学医学院进行，并由放射学和肿瘤学教授 Richard L. Wahl（医学博士、F.A.C.R.）和核医学教授 Henry N. Wagner, Jr. 监督，后者在使用 PET 进行 HBAT 方面做出了开创性工作/CT 扫描。这项工作的最终目标是用安全、更快、更便宜的微波辐射测量方法取代 PET/CT 的辐射和成本。只有通过新方法直接比较人体受刺激和无刺激HBAT状态下FDG的相对金标准，才能确定人体辐射测量操作特性。 公共健康相关性：拟议的计划旨在开发一种医疗设备，旨在帮助医疗保健专业人员更好地了解人类棕色脂肪在对抗肥胖方面的作用。这种更好的理解有望带来治疗肥胖症的改进方法，目前肥胖症的流行是造成许多疾病和过早死亡的原因。