Instrumentation for Creating Biological Stents and Occlusions

用于制造生物支架和闭塞物的仪器

• 批准号: 7477546
• 负责人: FRED STERZER
• 金额: $ 10.94万
• 依托单位: MMTC, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7477546
• 关键词: Adverse effects; Animal Experiments; Animals; Arteries; Benign Prostatic Hypertrophy; Bile fluid; Biological; Caliber; Catheters; Clinical; Communication; Disease; Distal; Duct (organ) structure; Frequencies; Heating; Human; Invasive; Length; Location; Measures; Medical; Medicine; Numbers; Operative Surgical Procedures; Outpatients; Pancreatic duct; Pattern; Peripheral; Phase; Physicians; Procedures; Production; Prostatic Urethra; Public Health; Research; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Stents; Temperature; Testing; Tissues; Today; United States Food and Drug Administration; United States National Institutes of Health; Varicosity; base; design; instrumentation; interest; interstitial; microwave electromagnetic radiation; novel; pressure; programs; prototype; size; solid state

DESCRIPTION (provided by applicant): The long-term objectives of the proposed research program are to provide the instrumentation required to perform minimally invasive procedures for safely dilating or occluding the lumens of canals, ducts or vessels that are located almost anywhere in the body. The procedures will not require the introduction of foreign materials into the body, materials that can sometimes cause serious side effects, and in many cases it will be possible to perform them on an outpatient basis. While the dilations and occlusion that are produced are likely to be long lasting, the procedures can be repeated if necessary. The instrumentation will consist of microwave generators operating in the 5800 75 MHz frequency band, and microwave catheters designed to produce biological stents or occlusions in various anatomical locations. The specific aims are to fabricate a prototype 5800 MHz solid-state generator, and microwave catheters designed for enlarging the lumens of bile and pancreatic ducts and of peripheral arteries, for occluding varicose veins. PUBLIC HEALTH RELEVANCE: The instrumentation that would result from the proposed program would enable physicians to safely enlarge the diameter of many important human canals, ducts, and vessels that are narrowed by disease, or to close them as is sometimes necessary. The physicians will be often be able to accomplish this on an outpatient basis and without having to introduce foreign materials into the body, materials that can sometime cause serious side effects.

描述（由申请人提供）：拟议研究计划的长期目标是提供执行微创手术所需的仪器，以安全地扩张或闭塞几乎位于身体任何部位的运河、导管或血管的管腔。该手术不需要将异物引入体内，这些材料有时会导致严重的副作用，并且在许多情况下可以在门诊进行。虽然产生的扩张和闭塞可能会持续很长时间，但如有必要，可以重复该过程。该仪器将包括在 5800 75 MHz 频段运行的微波发生器，以及设计用于在不同解剖位置产生生物支架或闭塞物的微波导管。具体目标是制造原型 5800 MHz 固态发生器和微波导管，设计用于扩大胆管、胰管和外周动脉的管腔，以闭塞静脉曲张。公共健康相关性：拟议计划产生的仪器将使医生能够安全地扩大因疾病而变窄的许多重要的人体运河、管道和血管的直径，或者在有时必要时关闭它们。医生通常能够在门诊完成这一任务，而无需将异物引入体内，这些异物有时会导致严重的副作用。