Long Field Of View MRA Using Continuous Table Motion

使用连续工作台运动的长视场 MRA

• 批准号: 7915510
• 负责人: Stephen J Riederer
• 金额: $ 38.43万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7915510
• 关键词: Abdomen; Acceleration; Accounting; Age; Aging; Algorithms; Anatomy; Angiography; Applications Grants; Arteries; Blood flow; Bolus Infusion; Detection; Development; Diagnosis; Diagnostic; Dimensions; Distal; Dose; Goals; Image; Intravenous; Investigation; Lateral; Leg; Lower Extremity; Magnetic Resonance Imaging; Measures; Methodology; Methods; Morphologic artifacts; Motion; Patients; Pelvis; Peripheral; Peripheral Vascular Diseases; Phase; Physics; Physiologic pulse; Physiological; Population; Positioning Attribute; Preparation; Property; R-factor; Resolution; Scanning; Signal Transduction; Simulate; Speed; Techniques; Testing; Time; United States; computerized data processing; data acquisition; experience; foot; improved; in vivo; method development; public health relevance; reconstruction; research clinical testing; resistance factors

DESCRIPTION (provided by applicant): The long term objective of this project continues to be the development of methods which permit MR data acquisition during continuous motion of the patient table for contrast-enhanced MR angiographic studies of the peripheral vasculature. This will allow diagnostic quality imaging of the vasculature from the abdomen and pelvis to the feet to allow diagnosis and characterization of peripheral vascular disease. Imaging during continuous table motion permits high efficiency in the use of scan time and of the contrast dose. Because a given axial level is imaged within the moving field-of-view for only a limited time, typically 20 sec or less, it is critical to allow improvements in spatial resolution for a given acquisition time. To this end, acceleration techniques demonstrated in Years 01-04 in one dimension will be extended to the two lateral dimensions. Another major aim of the study is to image the contrast dose transit in real time, automatically track its position, and use this information to automatically adjust the table velocity. The grant application includes the following specific aims: 1. High Resolution CE-MRA of a Fixed FOV Using 2D Acceleration Techniques. In preparation for imaging during continuous table motion, techniques will first be developed for performing highly accelerated acquisitions during no table motion within a targeted 16 sec. The elliptical centric view order will be combined with 2D homodyne, 2D SENSE, and time-resolved view-shared acquisition for 1 mm isotropic resolution. 2. Parallel Acquisition Techniques Applied During Continuous Table Motion. The accelerated acquisition methods of Aim #1 will be adapted to continuously moving table imaging. Reconstruction algorithms will be developed which account for gradient warping, 2D SENSE-homodyne, and variable FOV acquisition. Coils will be developed which allow efficient 15x accelerated 2D parallel acquisition over an extended FOV. 3. Patient-Specific Acquisition for Continuously Moving Table Peripheral MRA. Methods will be developed to detect the leading edge of the contrast bolus as it moves along the peripheral vasculature and then to use this information to alter the patient table motion in real time. This will be tested initially in phantoms and then using a test bolus. The final technique will be one in which an extended-FOV, high spatial resolution, arterial phase peripheral angiogram is formed by automatically tracking the full contrast bolus with no need for a test bolus. PUBLIC HEALTH RELEVANCE: Peripheral vascular disease is a major problem in the population of the United States, and it is important to image and diagnosis this condition in an easy, accurate, reliable, safe manner which not only accounts for patient-to-patient differences in anatomy and blood flow but also accommodates the long field of view which ex- tends from the abdomen to the feet. This project is relevant to this problem, as the goal is to develop a method which allows high spatial resolution MR imaging of the extended vasculature by using a moving patient table uniquely tuned to the transit of intravenous contrast material within each patient.

描述（由申请人提供）：该项目的长期目标仍然是开发允许在患者台连续运动期间采集 MR 数据的方法，用于外周脉管系统的对比增强 MR 血管造影研究。这将能够对从腹部、骨盆到脚部的脉管系统进行高质量的诊断成像，从而能够诊断和表征周围血管疾病。工作台连续运动过程中的成像可以高效地利用扫描时间和造影剂剂量。由于给定的轴向水平仅在有限的时间内（通常为 20 秒或更短）在移动视场内成像，因此提高给定采集时间内的空间分辨率至关重要。为此，01-04年在一维展示的加速技术将扩展到两个横向维度。该研究的另一个主要目的是实时成像造影剂量传输，自动跟踪其位置，并使用该信息自动调整工作台速度。该拨款申请包括以下具体目标： 1. 使用 2D 加速技术对固定 FOV 进行高分辨率 CE-MRA。为了准备连续工作台运动期间的成像，首先将开发在目标 16 秒内无工作台运动期间执行高度加速采集的技术。椭圆中心视图顺序将与 2D 零差、2D SENSE 和时间分辨视图共享采集相结合，以实现 1 毫米各向同性分辨率。 2.连续工作台运动期间应用的并行采集技术。目标#1 的加速采集方法将适用于连续移动的工作台成像。将开发考虑梯度扭曲、2D SENSE 零差和可变 FOV 采集的重建算法。将开发的线圈可在扩展视场内实现高效的 15 倍加速 2D 并行采集。 3. 针对连续移动台外周 MRA 的患者特定采集。将开发方法来检测造影剂沿着外周脉管系统移动时的前缘，然后使用该信息实时改变患者台运动。最初将在模型中进行测试，然后使用测试推注进行测试。最终技术将是通过自动跟踪完整对比剂团而形成扩展视场、高空间分辨率、动脉期外周血管造影照片，而无需测试团剂。公共卫生相关性：外周血管疾病是美国人口的一个主要问题，以简单、准确、可靠、安全的方式对这种疾病进行成像和诊断非常重要，这不仅考虑到患者之间的差异不仅符合解剖学和血流，而且还适应从腹部延伸到脚部的长视野。该项目与这个问题相关，因为目标是开发一种方法，通过使用专门针对每位患者体内静脉造影材料的传输进行独特调整的移动患者台，对扩展的脉管系统进行高空间分辨率 MR 成像。