Emergence of Adolescent Substance Use Problems from the Externalizing Spectrum

从外化谱来看青少年药物使用问题的出现

基本信息

批准号：
7935282
负责人：
Kevin Michael King
金额：
$ 42.62万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7935282
关键词：
Address Adolescence Adolescent Adult Age Aggressive behavior Alcohol or Other Drugs use Alcohols Antisocial Personality Disorder Area Attention Attention deficit hyperactivity disorder Behavior Child Childhood Clinical Research Communities Conduct Disorder Data Data Analyses Data Reporting Data Set Development Disease Evaluation Exhibits Goals Growth Health Care Costs Hyperactive behavior Impulsivity Individual Intervention Knowledge Label Longevity Longitudinal Studies Measurement Measures Mediating Methods Modeling Neighborhoods Oppositional Defiant Disorder Pathway interactions Pharmaceutical Preparations Plant Roots Prevention Preventive Process Psychometrics Public Health Race Research Research Priority Risk Rural Sampling Screening procedure Structure Substance Use Disorder Symptoms Testing Time adolescent substance use anti social cost design disinhibitory psychopathology early adolescence externalizing behavior high risk inattention innovation insight kindergarten prevent product development response sex teacher

项目摘要

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (04) Clinical Research and Specific Challenge Topic, 04-DA-102: A New Look at Longitudinal Data. Prior research has consistently indicated that adolescents who are at risk for developing substance use disorders exhibit externalizing behavior problems, including higher levels of conduct problems (e.g., oppositional behavior, aggression, delinquency) and attention-deficit/hyperactivity (ADHD) symptoms (i.e., inattention, hyperactivity, impulsivity). Recent research has identified a phenotypic vulnerability to disinhibitory psychopathology, called the externalizing spectrum, which is believed to underlie the development of substance use, problems, and disorder during adolescence and adulthood, and externalizing behavior problems that occur across the lifespan (ADHD, oppositional defiant disorder, conduct disorder, and antisocial personality disorder). Yet developmental models of the externalizing spectrum have not been tested, nor has the emergence of substance use and problems within the externalizing spectrum been examined. Given the public health costs associated with substance use, it is imperative to study the process by which substance use disorders emerge and where, when, or with whom it is possible to intervene in order to prevent the development of substance use problems and disorder. The proposed study will capitalize on an extensive longitudinal data set, the Fast Track project, to examine the relationships between different indicators of the externalizing spectrum from childhood to late adolescence. Fast Track was a multisite, longitudinal study that conducted annual evaluations from kindergarten to age 20 in a community sample of children (n = 754) at high risk for serious conduct problems, who were identified from a screening sample of 9,454 children. The first goal of the proposed research is to use the screening and longitudinal samples to develop a developmentally sensitive model of the externalizing spectrum (including substance use) within three developmental periods (childhood, early adolescence, and late adolescence), with a specific focus on testing whether the psychometric structure of the externalizing spectrum is consistent across time, sex, race, and neighborhood setting (urban vs. rural). The second goal is to test whether the externalizing spectrum can be represented by a single higher-order factor across developmental periods, and to determine whether the underlying externalizing spectrum is best characterized as categorical (i.e., qualitatively distinct pathways of development) or continuous (i.e., continuum of externalizing problems throughout adolescence). Ultimately, the results from these secondary data analyses will provide insight into potential targets for the prevention and treatment of substance use, problems, and disorders. This project will increase understanding of how the "externalizing spectrum" of behaviors is expressed from childhood through late adolescence. It will also examine how substance use, problems, and disorder emerge as part of the externalizing spectrum across this developmental period. This has important implications for designing more effective preventive and treatment interventions for substance use and related problems.

描述（由申请人提供）：本申请涉及广泛的挑战领域 (04) 临床研究和特定挑战主题，04-DA-102：纵向数据的新视角。先前的研究一致表明，有患药物滥用障碍风险的青少年表现出外化行为问题，包括较高水平的行为问题（例如，对抗行为、攻击性、犯罪）和注意力缺陷/多动（ADHD）症状（即，注意力不集中、多动、冲动）。最近的研究发现了一种对去抑制性精神病理学的表型脆弱性，称为外化谱，它被认为是青春期和成年期间物质使用、问题和障碍的发展的基础，以及整个生命周期中发生的外化行为问题（ADHD、对立违抗性）障碍、行为障碍和反社会人格障碍）。然而，外化谱的发展模型尚未经过测试，物质使用的出现和外化谱内的问题也尚未得到检验。考虑到与物质使用相关的公共卫生成本，有必要研究物质使用障碍出现的过程，以及在何处、何时或与谁可以进行干预，以防止物质使用问题和障碍的发展。拟议的研究将利用广泛的纵向数据集（快速通道项目）来检查从童年到青春期后期的外化谱的不同指标之间的关系。 Fast Track 是一项多地点纵向研究，对社区样本（n = 754）进行从幼儿园到 20 岁的严重行为问题高风险儿童样本的年度评估，这些儿童是从 9,454 名儿童的筛查样本中选出的。拟议研究的第一个目标是利用筛选和纵向样本来开发三个发育阶段（儿童期、青春期早期和青春期晚期）内外化谱（包括物质使用）的发育敏感模型，特别关注测试外化谱的心理测量结构在时间、性别、种族和邻里环境（城市与农村）之间是否一致。第二个目标是测试外化谱是否可以由跨发育时期的单个高阶因素来表示，并确定潜在的外化谱是否最好被描述为分类（即，定性上不同的发展路径）或连续（即，发展路径）。，整个青春期的外化问题的连续体）。最终，这些二次数据分析的结果将为预防和治疗药物滥用、问题和疾病的潜在目标提供见解。该项目将增进对从童年到青春期晚期行为的“外化谱”如何表达的理解。它还将研究物质使用、问题和障碍是如何作为整个发展时期外化谱的一部分出现的。这对于针对药物滥用和相关问题设计更有效的预防和治疗干预措施具有重要意义。