Cortical Control of a Dextrous Prosthetic Hand

灵巧假手的皮质控制

• 批准号: 7922526
• 负责人: ANDREW B. SCHWARTZ
• 金额: $ 102.6万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-18 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7922526
• 关键词: Address; Algorithms; Animals; Area; Arizona; Artificial Arm; Behavior; Behavioral; Binocular Vision; Brain; Categories; Cells; Characteristics; Collaborations; Complex; Cues; Data; Development; Devices; Diffuse; Dimensions; Engineering; Esthesia; Feedback; Fingers; Food; Freedom; Funding; Generations; Goals; Hand; Hand functions; Human; Individual; Joints; Knowledge; Laboratories; Laboratory Research; Learning; Link; Location; Locomotion; Maintenance; Maps; Mechanics; Minnesota; Modeling; Monkeys; Motor; Movement; Neurons; Neurosciences; Oral cavity; Output; Pattern; Performance; Phase; Population; Positioning Attribute; Primates; Pronation; Prosthesis; Psychophysiology; Recording of previous events; Research; Research Personnel; Robot; Robotics; Rotation; Scheme; Sensory; Shapes; Signal Transduction; Statistical Models; Stimulus; Structure; Supination; System; Thumb structure; Training; Translating; Universities; Work; Wrist; arm; design; grasp; interest; microstimulation; mind control; neuroregulation; object shape; programs; relating to nervous system; research study; response; sample fixation; sensory cortex; somatosensory; success; tool

DESCRIPTION (provided by applicant): The goal of this project is to build and demonstrate an anthropomorphic prosthetic arm and hand that is controlled by cortical output. The human arm and hand have approximately 30 degrees- of-freedom (dot- independent joint rotations) and are very complex mechanical structures. Hands are an example of an advanced evolutionary specialization, which along with binocular vision and bipedal locomotion, led to tool use- a major determinant of human brain development and behavior. Yet, little is known about the neural control of the hand during natural behavior. Regarding active prosthetic hands, there has been a paucity of work on robot hand control and only recently has there been an effort to make a truly accurate functioning hand replica. Primate reach-to-grasp behavior is characterized by four components- reach, hand shaping, orientation and the closing of the fingers around the object. Dexterity, characterized by the active generation of force through the fingertips to maintain stable grasp and/or to manipulate an object, can be considered as an additional component of hand behavior. Given our success in developing an anthropomorphic arm prosthesis, we expect to extract the signals necessary to achieve dexterous prosthetic hand control using activity recorded from populations of single neurons. In our present arm-only control scheme, we have successfully extracted the velocity of the arm from the recorded brain activity. To reach our ultimate goal of dexterous control, we will also need to control wrist orientation, hand shape and finger force application. Since each of these control categories is multidimensional, the overall control problem is very difficult. We will use a number of strategies to address this difficult problem. An interdisciplinary team of neurophysiologists, engineers, statisticians, robotocists and psychophysicists with a strong history of collaboration has been assembled to develop the pieces needed for this project. The project will be led by Andrew Schwartz at the University of Pittsburgh where the prosthetic control will take place. Yoky Matsuoka at Carnegie Mellon will build the highly anthropomorphic robots and behavioral manipulanda. Rob Kass, also at Carnegie Mellon, will develop the extraction algorithms relating neural activity to movement. Marco Santello and Stephen Helms-Tillery at Arizona State University will develop the behavioral tasks using a primate model and then record cortical activity as these tasks are performed. Dr. Soechting, at the University of Minnesota, will provide detailed psychophysical data describing the way subjects exert finger forces to manipulate objects. Peter Allen, at Columbia, will develop automated robotic grasp and finger placement algorithms for the brain-controlled prosthetic hand.

描述（由申请人提供）：该项目的目标是构建并演示由皮质输出控制的拟人化假肢手臂和手。人的手臂和手具有大约 30 度的自由度（点独立的关节旋转），并且是非常复杂的机械结构。手是高级进化专门化的一个例子，它与双眼视觉和双足运动一起导致了工具的使用——这是人类大脑发育和行为的主要决定因素。然而，人们对自然行为过程中手的神经控制知之甚少。关于主动假手，机器人手控制方面的工作很少，直到最近才开始努力制造真正精确的功能性手复制品。灵长类动物的伸手抓握行为由四个部分组成：伸手、手部形状、方向以及手指围绕物体的闭合。敏捷性的特征是通过指尖主动产生力以保持稳定的抓握和/或操纵物体，可以被视为手部行为的附加组成部分。鉴于我们在开发拟人手臂假肢方面取得了成功，我们希望利用从单个神经元群体记录的活动来提取实现灵巧假手控制所需的信号。在我们目前的仅手臂控制方案中，我们成功地从记录的大脑活动中提取了手臂的速度。为了达到灵巧控制的最终目标，我们还需要控制手腕方向、手部形状和手指施力。由于每个控制类别都是多维的，因此总体控制问题非常困难。我们将使用多种策略来解决这个难题。一个由神经生理学家、工程师、统计学家、机器人学家和心理物理学家组成的跨学科团队已经组建起来，他们具有悠久的合作历史，以开发该项目所需的部件。该项目将由匹兹堡大学的安德鲁·施瓦茨（Andrew Schwartz）领导，假肢控制将在那里进行。卡内基梅隆大学的 Yoky Matsuoka 将建造高度拟人化的机器人和行为操纵器。同样来自卡内基梅隆大学的 Rob Kass 将开发将神经活动与运动相关的提取算法。亚利桑那州立大学的 Marco Santello 和 Stephen Helms-Tillery 将使用灵长类动物模型开发行为任务，然后在执行这些任务时记录皮质活动。明尼苏达大学的 Soechting 博士将提供详细的心理物理学数据，描述受试者施加手指力量来操纵物体的方式。哥伦比亚大学的彼得·艾伦（Peter Allen）将为大脑控制的假手开发自动机器人抓取和手指放置算法。