Particles Research Core

粒子研究核心

基本信息

批准号：
7787766
负责人：
John J Godleski
金额：
$ 6.54万
依托单位：
HARVARD SCHOOL OF PUBLIC HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-01 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7787766
关键词：
Adrenergic alpha-Antagonists Aging Air Air Pollution Animal Model Animals Area Arrhythmia Autonomic nervous system Biological Blood Pressure Blood Vessels Blood flow Boston Breathing Canis familiaris Cardiac Cardiovascular system Cause of Death Cessation of life Clinical Complex Coronary Coronary artery Development Epidemiology Exposure to Fiber Fostering Genetic Gold Grant Health Heart Heart Atrium Heart Block Hour Human Hypotension Implant Inhalation Exposure Investigation Ischemia Laboratories Laboratory Study Lead Leadership Link Lung Measurement Measures Mediating Modeling Mutation Myocardial Infarction Myocardial Ischemia National Institute of Environmental Health Sciences Nucleosome Core Particle Occupational Outcome Particulate Pattern Peptides Perfusion Physiological Pilot Projects Play Pollution Population Population Study Preparation Pressoreceptors Process Public Health Reactive Oxygen Species Research Research Personnel Research Project Grants Resistance Scientist Technology Time Work ambient particle awake base brachial artery diabetic gene environment interaction heart rate variability metropolitan monitoring device mortality particle particle exposure reactive hyperemia relating to nervous system respiratory response

项目摘要

Under the leadership of Dr. John Godleski MD, the Particles Core brings together basic, clinical, and public health scientist to work in concert to make substantial progress in our understanding of human health effects that result from ambient particle exposure and the biological mechanisms responsible for these effects. For example, investigators of this core were among the first to epidemiologically define cardiovascular deaths as very important outcomes related to increases in ambient air pollution (Dockery, Pope et al. 1993; Schwartz 1999). In population studies, Center investigators and others identified short term outcomes, such as heart rate variability and arrhythmias that served as potential markers that could lead to cardiovascular deaths and were associated with exposure to increases in ambient particles (Pope, Verrier et al. 1999; Gold, Litonjua et al. 2000). These findings were defined in human populations, technologies were developed to use real particulate ambient air pollution in laboratory settings to study toxicological mechanisms (Sioutas, Koutrakis et al. 1995; Godleski, Vernier et al. 2000), and laboratory models with both large and small animals were developed for mechanistic studies (Clarke, Catalano et al. 1999; Godleski, Verrier et al. 2000; Gurgueira, Lawrence et al. 2002; Wellenius, Saldiva et al. 2002; Wellenius, Coull et al. 2003). In the past three years, interactions between basic scientist and epidemiological investigators fostered by this NIEHS center have substantially accelerated this area of research. The iterative process has resulted in a clearer understanding of who is susceptible, and by what mechanisms do the responses result in adverse health outcomes. Most importantly, we have begun to reach a level of understanding in which multiple diverse outcomes are mechanistically linked.

在医学博士约翰·戈德莱斯基 (John Godleski) 博士的领导下，粒子核心团队汇集了基础、临床和公共卫生科学家，共同努力，在我们对环境粒子暴露对人类健康的影响以及造成这种影响的生物机制的理解方面取得了实质性进展。这些影响。例如，该核心研究人员是最早从流行病学角度将心血管死亡定义为与环境空气污染增加相关的非常重要的结果的人之一（Dockery、Pope 等人，1993 年；Schwartz） 1999）。在人口研究中，中心研究人员和其他人确定了短期结果，例如心率变异性和心律失常，它们是可能导致心血管死亡的潜在标志，并且与暴露于环境颗粒物增加有关（Pope、Verrier 等人，1999 年；金，Litonjua 等人。 2000）。这些发现是在人群中定义的，技术的发展是为了在实验室环境中使用真实的颗粒物环境空气污染来研究毒理学机制（Sioutas、Koutrakis 等人，1995 年；戈德莱斯基，韦尔尼尔等人。 2000），并开发了大型和小型动物的实验室模型用于机械研究（Clarke，Catalano 等人，1999 年；Godleski，Verrier 等人，2000 年；Gurgueira，Lawrence 等人，2000 年）。 2002年； Wellenius，萨尔迪瓦等人。 2002年； Wellenius，库尔等人。 2003）。在过去的三年里，NIEHS 中心促进的基础科学家和流行病学研究人员之间的互动极大地加速了这一领域的研究。迭代过程使我们更清楚地了解谁是易受影响，以及这些反应通过什么机制导致不良的健康结果。最重要的是，我们已经开始达到多种不同结果机械联系在一起的理解水平。